Skip Navigation LinksHome > July/August 2011 - Volume 35 - Issue 4 > Gd-EOB-DTPA as a Functional MR Cholangiography Contrast Agen...
Journal of Computer Assisted Tomography:
doi: 10.1097/RCT.0b013e31821f4e29
Abdominal Imaging

Gd-EOB-DTPA as a Functional MR Cholangiography Contrast Agent: Imaging Gallbladder Filling in Patients With and Without Hepatobiliary Dysfunction

Smith, Andrew Dennis MD, PhD*; Veniero, Joseph C. MD, PhD†

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Objective: To evaluate cystic duct patency on hepatobiliary-phase magnetic resonance (MR) images after intravenous gadolinium ethoxybenzyl diethylenetriamine pentaacetic acid (Gd-EOB-DTPA) administration.

Methods: A radiology information system search identified patients with gallbladders that had MR imaging after intravenous Gd-EOB-DTPA injection. No patients had acute cholecystitis. Magnetic resonance image findings were correlated with clinical notes, other imaging studies, time of contrast injection, and serum laboratory tests.

Results: Contrast accumulated in the gallbladder in 80% of patients (n = 100) with hepatobiliary-phase MR imaging at a median of 22 minutes (range, 15-83 minutes). Absence of contrast accumulation in the gallbladder (n = 20) was associated with hepatobiliary imaging less than 30 minutes after contrast administration, gallbladder contraction, cholelithiasis, elevated liver function tests, elevated bilirubin, and cirrhosis.

Conclusions: Functional assessment of cystic duct patency by Gd-EOB-DTPA-enhanced liver MR is best conducted when hepatobiliary-phase T1-weighted imaging is delayed by more than 30 minutes after contrast injection. Hepatobiliary dysfunction is associated with nonfilling of the gallbladder.

© 2011 Lippincott Williams & Wilkins, Inc.



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