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Detecting Disease Extent and Activity of Takayasu Arteritis Using Whole-Body Magnetic Resonance Angiography and Vessel Wall Imaging as a 1-Stop Solution

Li, Dan MD; Lin, Jiang MD; Yan, Fuhua MD

Journal of Computer Assisted Tomography: July-August 2011 - Volume 35 - Issue 4 - p 468-474
doi: 10.1097/RCT.0b013e318222d698
Cardiovascular Imaging

Purpose: The aim of the study was to assess vessel involvement and activity of Takayasu arteritis (TA) with whole-body magnetic resonance angiography (MRA) and vessel wall imaging.

Methods: Whole-body MRA was performed in 42 patients with TA. In 23 of them, precontrast and postcontrast high-resolution vessel wall imagings were acquired. Three of 23 patients had follow-up imaging after medical treatment. According to TA activity criteria, these 26 vessel wall imagings were clinically divided into 2 groups: active (n = 18) and remissive group (n = 8). Vessel wall thickness and postcontrast signal intensity of vessel wall relative to adjacent muscle were analyzed.

Results: Whole-body MRA yielded a diagnostic image of systemic and pulmonary artery. For vessel wall imaging, wall thickness of the active group (6.12 ± 1.1 mm) was thicker than that of the remissive group (4.31 ± 0.98 mm; P < 0.05). Postcontrast signal intensity ratio was significantly different between 2 groups (active vs remissive, 1.56 ± 0.40 vs 1.17 ± 0.21, P < 0.05). Based on the abnormalities revealed by combined whole-body MRA and vessel wall imaging, Lupi-Herrera's classification was modified in 8 of 23 patients.

Conclusions: Whole-body MRA combined with vessel wall imaging had the potential for a comprehensive evaluation of disease extent and activity of TA.

From the Department of Diagnostic Radiology, Shanghai Zhongshan Hospital, Shanghai Medical College of Fudan University, Shanghai, China.

Received for publication March 30, 2011; accepted May 4, 2011.

Reprints: Jiang Lin, MD, Department of Diagnostic Radiology, Shanghai Zhongshan Hospital, Shanghai Medical College of Fudan University, Shanghai 200032, China (e-mail: lin.jiang@zs-hospital.sh.cn).

The authors have no financial disclosure to report.

© 2011 Lippincott Williams & Wilkins, Inc.