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Role of Diffusion-Weighted Magnetic Resonance Imaging in Characterization of Renal Tumors

Razek, Ahmed Abdel Khalek Abdel MD*; Farouk, Ahmed MD; Mousa, Amani MD*; Nabil, Nancy MD

Journal of Computer Assisted Tomography: May-June 2011 - Volume 35 - Issue 3 - p 332-336
doi: 10.1097/RCT.0b013e318219fe76
Abdominal Imaging

Objective: To evaluate the role of diffusion-weighted magnetic resonance (MR) imaging in the characterization of renal tumors.

Materials and Methods: Prospective study was conducted on 52 consecutive patients (24 males and 28 females) with renal tumor. They underwent diffusion-weighted echo planar MR imaging of the abdomen with b-factor of 0 and 800 seconds/mm2. The apparent diffusion coefficient (ADC) value of the renal tumor was calculated and correlated with histopathological results.

Results: The mean ADC value of malignant renal tumors (1.56 ± 0.26 × 10−3 mm2/s) was significantly different (P = 0.001) from that of benign tumors (1.87 ± 0.50 × 10−3 mm2/s). Selection of 1.84 × 10−3 mm2/s as a cutoff point of ADC value to predict renal malignancy revealed accuracy of 89%, sensitivity of 89%, and specificity of 89%. The cutoff point of ADC value to differentiate renal cell carcinoma (RCC) from other malignancy (1.15 × 10−3 mm2/s) revealed 72% accuracy, 95% sensitivity, 50% specificity. The cutoff point of ADC value used to differentiate clear and papillary RCC from other subtypes of RCC was 1.84 × 10−3 mm2/s with an accuracy of 89%, sensitivity of 89%, and specificity of 89%.

Conclusion: Apparent diffusion coefficient value can differentiate benign from malignant renal tumors and may be helpful for the differentiation of the histologic subtypes of RCC.

From the *Diagnostic Radiology Department, Mansoura Faculty of Medicine, Mansoura University Hospital; and †Diagnostic Radiology Department, Mansoura Urology and Nephrology Center, Mansoura, Egypt.

Received for publication December 24, 2010; accepted March 11, 2011.

Reprints: Ahmed Abdel Khalek Abdel Razek, MD, Diagnostic Radiology Department, Mansoura Faculty of Medicine, Elgohmeryia Street, Mansoura, Egypt 3512 (e-mail: arazek@mans.edu.eg).

© 2011 Lippincott Williams & Wilkins, Inc.