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Magnetic Resonance Manifestations of Hyperreactio Luteinalis

Takeuchi, Mayumi MD, PhD; Matsuzaki, Kenji MD, PhD

Journal of Computer Assisted Tomography:
doi: 10.1097/RCT.0b013e318218c09e
Abdominal Imaging

Objective: Hyperreactio luteinalis (HL) is a rare benign physiological ovarian enlargement associated with gestational trophoblastic disease or pregnancy, and may mimic neoplasm. We evaluated magnetic resonance findings of HL to distinguish from neoplasm by using diffusion-weighted imaging with apparent diffusion coefficient (ADC) measurement.

Methods: Magnetic resonance manifestations of 15 cases of HL in 8 women (mean age, 32 years) were retrospectively evaluated. Diffusion-weighted imaging (b = 0 and 800 seconds/mm2) was obtained in 11 cases of HL, and ADC was compared with that in solid portions of 18 ovarian cancers.

Results: All cases of HL appeared as multilocular cystic masses with septations mimicking mucinous cystic tumors. Intervening ovarian stroma exhibited hyperintensity on diffusion-weighted imaging. The ADC in ovarian stroma in HL was significantly higher than that in solid portions of ovarian cancers.

Conclusion: Ovarian stroma in HL may mimic solid tumorous components in mucinous tumors; however, high ADC reflecting edematous, luteinized stroma may be helpful for the diagnosis of HL.

Author Information

From the Department of Radiology, University of Tokushima, Tokushima, Japan.

Received for publication November 28, 2010; accepted March 4, 2011.

Reprints: Mayumi Takeuchi, MD, PhD, Department of Radiology, University of Tokushima, 3-18-15, Kuramoto-cho, Tokushima, 770-8503, Japan (e-mail:

Both authors have no conflicts of interest and have received no funding for research.

© 2011 Lippincott Williams & Wilkins, Inc.