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Effect of Lapatinib on Hepatic Parenchymal Enhancement on Gadoxetate Disodium (EOB)-Enhanced MRI Scans

Nakamura, Yuko MD*; Date, Shuji MD*; Toyota, Naoyuki MD†; Tani, Chihiro MD*; Honda, Yukiko MD*; Komoto, Daisuke MD*; Tanitame, Keizo MD*; Awai, Kazuo MD*

Journal of Computer Assisted Tomography: May/June 2011 - Volume 35 - Issue 3 - pp 351-352
doi: 10.1097/RCT.0b013e31821a02aa
Abdominal Imaging

We present changes seen on hepatobiliary phase (HBP)-gadoxetate disodium (EOB)-enhanced magnetic resonance image of a woman with liver metastases who was treated with lapatinib. After treatment, the HBP images appeared like portal venous phase images. This suggests that lapatinib, an inhibitor of organic anion transporting polypeptide 1B1, one of the substrates of EOB, inhibits EOB uptake by hepatocytes. In patients treated with lapatinib, the ability to diagnose liver tumors on HBP images may be compromised.

From the *Department of Diagnostic Radiology, Graduate School of Biomedical Sciences, Hiroshima University, Hiroshima; and †Department of Radiology, National Hospital Organization Kure Medical Center and Chugoku Cancer Center, Kure, Japan.

Received for publication February 24, 2011; accepted March 11, 2011.

Reprints: Yuko Nakamura, MD, Diagnostic Radiology, Graduate School of Biomedical Sciences, Hiroshima University, 1-2-3 Kasumi, Minami-ku, Hiroshima, Hiroshima, Japan (e-mail: yukon@hiroshima-u.ac.jp).

The authors did not receive funding for this work, and they have no conflicts of interest.

© 2011 Lippincott Williams & Wilkins, Inc.