Skip Navigation LinksHome > January/February 2011 - Volume 35 - Issue 1 > The Accuracy of Computed Tomographic Perfusion in Detecting...
Journal of Computer Assisted Tomography:
doi: 10.1097/RCT.0b013e3181f01b93
Original Articles

The Accuracy of Computed Tomographic Perfusion in Detecting Recurrent Nasopharyngeal Carcinoma After Radiation Therapy

Jin, Guanqiao MD; Su, Danke MD; Liu, Lidong MD; Zhu, Xuna MD; Xie, Dong MD; Zhao, Wei MD

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Objectives: To assess the diagnostic accuracy of computed tomographic (CT) perfusion technique in discriminating recurrent nasopharyngeal carcinoma (NPC) after radiation therapy.

Methods: Forty-eight patients with a pathologic finding as reference standards were divided into 2 groups, recurrent and nonrecurrent NPCs. Perfusion parameters blood flow (BF), blood volume (BV), permeability surface (PS), and mean transit time were statistically analyzed. A receiver operating characteristic curve was used to study whether CT perfusion parameters could aid in detecting recurrent NPC.

Results: Blood flow, BV, and PS values between recurrent NPC (n = 27) and nonrecurrent NPC (n = 21) were 526.8 (168.1) versus 312.1 (214.4) mL/100 g per minute, 35.1 (23.6) versus 9.2 (8.0) (ml/100 g), and 53.4 (34.3) versus 17.6 (14.7) mL/100 g per minute, respectively. There was a significant difference between these 2 groups (P < 0.01). Mean transit time values in these 2 groups were 3.5 (2.0) versus 4.3 (2.7) seconds; there was no statistical difference. To optimize sensitivity and specificity, BF, BV, and PS threshold values for differentiating between recurrent and nonrecurrent NPCs were 537.20 mL/100 g per minute, 37.18 (ml/100 g), and 57.34 mL/100 g per minute, respectively. According to threshold values of BF, BV, and PS, sensitivity and specificity for distinguishing recurrent and nonrecurrent NPCs were 92.6% and 76.2%, 96.3% and 81%, and 81.5% and 61.9%, respectively.

Conclusions: The CT perfusion technique may be helpful to find patients with recurrent NPC after radiation therapy.

© 2011 Lippincott Williams & Wilkins, Inc.



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