Skip Navigation LinksHome > January/February 2011 - Volume 35 - Issue 1 > High-Temporal Resolution Dual-Energy Computed Tomography of...
Journal of Computer Assisted Tomography:
doi: 10.1097/RCT.0b013e3181f87475
Original Articles

High-Temporal Resolution Dual-Energy Computed Tomography of the Heart Using a Novel Hybrid Image Reconstruction Algorithm: Initial Experience

Nance, John William Jr MD*; Bastarrika, Gorka MD, PhD*†; Kang, Doo Kyoung MD*‡; Ruzsics, Balazs MD, PhD*§; Vogt, Sebastian PhD∥; Schmidt, Bernhard PhD∥; Raupach, Rainer PhD∥; Flohr, Thomas G. PhD∥; Schoepf, U. Joseph MD*§

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Objectives: Dual-energy computed tomography (DECT) has been proposed for the comprehensive assessment of coronary artery stenosis and myocardial perfusion yet traditionally required reducing the temporal resolution of cardiac studies. We evaluated a reconstruction algorithm that preserves high temporal resolution at cardiac DECT.

Methods: Twelve consecutive patients (3 women; mean [SD] age, 64 [10] years) with an abnormal single photon emission CT result underwent invasive coronary angiography and cardiac DECT. Dual-energy CT studies were reconstructed using the standard algorithm with 165-millisecond temporal resolution and a hybrid algorithm providing 83-millisecond temporal resolution. These studies were rated for coronary image quality and motion artifacts and compared with invasive coronary angiographic studies.

Results: One hundred sixty-eight coronary artery segments (82%) were evaluated. The standard 165-millisecond reconstruction provided 95% diagnostic segments compared with 100% using the 83-millisecond hybrid reconstruction. Image quality was rated significantly (P < 0.05) better with hybrid reconstruction and had 91.4% sensitivity, 94.7% specificity, 82.1% positive predictive value, and 97.7% negative predictive value for detecting significant stenosis versus 85.7%, 93.2%, 76.9%, and 96.1% with standard reconstruction, respectively.

Conclusions: Hybrid image reconstruction mitigates the former limitations in temporal resolution of cardiac DECT.

© 2011 Lippincott Williams & Wilkins, Inc.



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