Skip Navigation LinksHome > November/December 2010 - Volume 34 - Issue 6 > Whole-Brain Perfusion Measurement Using 320-Detector Row Com...
Journal of Computer Assisted Tomography:
doi: 10.1097/RCT.0b013e3181ebd16a

Whole-Brain Perfusion Measurement Using 320-Detector Row Computed Tomography in Patients With Cerebrovascular Steno-Occlusive Disease: Comparison With 15O-Positron Emission Tomography

Shinohara, Yuki MD; Ibaraki, Masanobu PhD; Ohmura, Tomomi BSc; Sugawara, Shigeki BSc; Toyoshima, Hideto BSc; Nakamura, Kazuhiro PhD; Kinoshita, Fumiko MD, PhD; Kinoshita, Toshibumi MD, PhD

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Objective: The 320-detector row computed tomography (CT) can provide whole-brain CT perfusion (CTP) maps with continuous angiographic images by performing a single dynamic scan. We investigated the reliability of CTP cerebral blood flow (CTP-CBF) with 320-detector row CT by comparing findings with 15O-positron emission tomography (PET-CBF).

Methods: Whole-brain CTP and PET were performed in 10 patients with chronic unilateral steno-occlusive disease. We compared absolute and relative CBF values of bilateral middle cerebral artery territories between CTP and PET.

Results: Although mean CTP-CBF values were approximately 30% lower than mean PET-CBF values, the mean ischemic-to-nonischemic CBF ratios of CTP and PET were almost identical (P = 0.804). Regression analysis showed a significant correlation between CTP-CBF and PET-CBF values for each patient (r = 0.52-0.85, P < 0.001).

Conclusions: Whole-brain CTP using 320-detector row CT is useful for evaluating the degree of ischemia for the entire brain with chronic cerebrovascular disease.

© 2010 Lippincott Williams & Wilkins, Inc.



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