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Whole-Brain Perfusion Measurement Using 320-Detector Row Computed Tomography in Patients With Cerebrovascular Steno-Occlusive Disease: Comparison With 15O-Positron Emission Tomography

Shinohara, Yuki MD; Ibaraki, Masanobu PhD; Ohmura, Tomomi BSc; Sugawara, Shigeki BSc; Toyoshima, Hideto BSc; Nakamura, Kazuhiro PhD; Kinoshita, Fumiko MD, PhD; Kinoshita, Toshibumi MD, PhD

Journal of Computer Assisted Tomography: November/December 2010 - Volume 34 - Issue 6 - pp 830-835
doi: 10.1097/RCT.0b013e3181ebd16a

Objective: The 320-detector row computed tomography (CT) can provide whole-brain CT perfusion (CTP) maps with continuous angiographic images by performing a single dynamic scan. We investigated the reliability of CTP cerebral blood flow (CTP-CBF) with 320-detector row CT by comparing findings with 15O-positron emission tomography (PET-CBF).

Methods: Whole-brain CTP and PET were performed in 10 patients with chronic unilateral steno-occlusive disease. We compared absolute and relative CBF values of bilateral middle cerebral artery territories between CTP and PET.

Results: Although mean CTP-CBF values were approximately 30% lower than mean PET-CBF values, the mean ischemic-to-nonischemic CBF ratios of CTP and PET were almost identical (P = 0.804). Regression analysis showed a significant correlation between CTP-CBF and PET-CBF values for each patient (r = 0.52-0.85, P < 0.001).

Conclusions: Whole-brain CTP using 320-detector row CT is useful for evaluating the degree of ischemia for the entire brain with chronic cerebrovascular disease.

From the Department of Radiology, Research Institute of Brain and Blood Vessels - Akita, Akita, Japan.

Received for publication May 14, 2010; accepted June 7, 2010.

Reprints: Yuki Shinohara, MD, Department of Radiology, Research Institute of Brain and Blood Vessels - Akita, 6-10 Senshu-kubota-machi, Akita 010-0874, Japan (e-mail:

This study had no source of financial support.

Copyright © 2010 Wolters Kluwer Health, Inc. All rights reserved.