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Journal of Computer Assisted Tomography:
doi: 10.1097/RCT.0b013e3181ec05e4
Musculoskeletal Radiology

Texture Analysis, Bone Mineral Density, and Cortical Thickness of the Proximal Femur: Fracture Risk Prediction

Rodríguez-Soto, Ana Elvira BSc*; Fritscher, Karl D. MD, PhD†; Schuler, Benedikt MSc†; Issever, Ahi S. MD*; Roth, Tobias MD‡; Kamelger, Florian MD‡; Kammerlander, Christian MD‡; Blauth, Michael MD‡; Schubert, Rainer MD†; Link, Thomas M. MD*

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Abstract

Objective: The objectives of this study were to perform a clinical study analyzing bone quality in multidetector computed tomographic images of the femur using bone mineral density (BMD), cortical thickness, and texture algorithms in differentiating osteoporotic fracture and control subjects; to differentiate fracture types.

Methods: Femoral head, trochanteric, intertrochanteric, and upper and lower neck were segmented (fracture, n = 30; control, n = 10). Cortical thickness, BMD, and texture analysis were obtained using co-occurrence matrices, Minkowski dimension, and functional and scaling index method.

Results: Bone mineral density and cortical thickness performed best in the neck region, and texture measures performed best in the trochanter. Only cortical thickness and texture measures differentiated femoral neck and intertrochanteric fractures.

Conclusions: This study demonstrates that differentiation of osteoporotic fracture subjects and controls is achieved with texture measures, cortical thickness, and BMD; however, performance is region specific.

© 2010 Lippincott Williams & Wilkins, Inc.

 

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