Skip Navigation LinksHome > November/December 2010 - Volume 34 - Issue 6 > Magnetic Resonance Dynamic Susceptibility-Weighted Contrast-...
Journal of Computer Assisted Tomography:
doi: 10.1097/RCT.0b013e3181ef77e2

Magnetic Resonance Dynamic Susceptibility-Weighted Contrast-Enhanced Perfusion Imaging in the Diagnosis of Posterior Fossa Hemangioblastomas and Pilocytic Astrocytomas: Initial Results

Kumar, Vinodh A. MD*; Knopp, Edmond A. MD†; Zagzag, David MD, PhD‡

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Objective: The purpose of this study was to compare the dynamic susceptibility-weighted contrast-enhanced (DSC) magnetic resonance (MR) perfusion and MR imaging findings between hemangioblastomas and pilocytic astrocytoma (PA).

Methods: We retrospectively identified 6 patients with hemangioblastomas and 8 patients with PAs who underwent MR imaging before resection. Using fluid-attenuated inversion-recovery imaging, we graded peritumoral edema as absent, minimal, mild, moderate, or severe. In addition, 3 patients with hemangioblastomas and 4 patients with PAs underwent DSC-MR imaging before resection.

Results: We observed moderate to severe peritumoral edema in 6 patients with hemangioblastomas and none or minimal peritumoral edema in 8 patients with PAs. The mean relative cerebral blood volume was 7.7 (SD, 1.0) in patients with hemangioblastomas and 1.8 (SD, 1.8) in patients with PAs.

Conclusions: Our preliminary findings demonstrate significantly higher DSC-MR imaging relative cerebral blood volumes in patients with hemangioblastomas when compared with patients with PAs. In addition, moderate to severe peritumoral edema was associated with hemangioblastomas.

© 2010 Lippincott Williams & Wilkins, Inc.



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