Skip Navigation LinksHome > May/June 2010 - Volume 34 - Issue 3 > Breath-Hold 1H-Magnetic Resonance Spectroscopy for Intrahepa...
Journal of Computer Assisted Tomography:
doi: 10.1097/RCT.0b013e3181cefb89
Abdominal Imaging

Breath-Hold 1H-Magnetic Resonance Spectroscopy for Intrahepatic Lipid Quantification at 3 Tesla

Bredella, Miriam A. MD*; Ghomi, Reza Hosseini MSE*; Thomas, Bijoy J. MD*; Ouellette, Hugue A. MD*; Sahani, Dushyant V. MD*; Miller, Karen K. MD†; Torriani, Martin MD*

Collapse Box

Abstract

Objective: To compare breath-hold 1H-magnetic resonance spectroscopy (1H-MRS) with respiratory-gated 1H-MRS and computed tomography (CT) for quantification of hepatic lipid content.

Methods: Twenty-three premenopausal women underwent breath-hold point-resolved single-voxel 1H-MRS of the liver followed by respiratory-gated 1H-MRS at 3 Tesla and CT slice through the liver. Interscan variability for 1H-MRS was assessed in 6 volunteers. Pearson correlation coefficients, Bland-Altman 95% limit of agreement, and concordance correlation coefficients were calculated.

Results: There was a strong correlation between breath-hold and respiratory-gated 1H-MRS (r = 0.94, P < 0.0001; concordance correlation coefficient, 0.75). Using Bland-Altman analysis, all but 2 data points were within the limits of agreement. Both 1H-MRS techniques had low interscan variability. There was an inverse correlation of both 1H-MRS techniques with CT attenuation values of the liver.

Conclusions: Breath-hold 1H-MRS is a reliable method to measure hepatic lipid content at 3 Tesla. Breath-hold 1H-MRS of the liver provides data that closely correlates with that obtained from longer-duration respiratory-gated technique.

© 2010 Lippincott Williams & Wilkins, Inc.

  

Login

Article Tools

Share

Article Level Metrics

Search for Similar Articles
You may search for similar articles that contain these same keywords or you may modify the keyword list to augment your search.