Osteonecrosis of the Tibial Plateau: Magnetic Resonance Imaging Appearances With Quantitation of Lesion Size and Evidence of a Pathogenesis of Meniscal InjuryTheodorou, Stavroula J. MD*†; Theodorou, Daphne J. MD*†; Agnantis, Niki J. MD‡; Soucacos, Panayotis N. MD§; Resnick, Donald MD*†Journal of Computer Assisted Tomography: January 2010 - Volume 34 - Issue 1 - p 149-155 doi: 10.1097/RCT.0b013e3181b12a7 Musculoskeletal Imaging Abstract Author Information Purpose: To determine the magnetic resonance (MR) imaging appearances of osteonecrosis of the tibial plateau and perform quantitative analysis of the extent of the necrotic area. Materials and Methods: Twenty-eight patients (34 knees) with osteonecrosis were retrospectively evaluated using MR imaging and other modalities where available. A computerized image analysis program that allowed quantification of the lesion size was used to obtain measurements of the extent of involvement, which were then incorporated into each stage of the disease. Results: The MR imaging findings of osteonecrosis of the tibial plateau included subchondral regions of abnormal signal intensity (n = 28), a double-line sign (n = 11), and fractures (n = 9). Meniscal tears and cartilage abnormalities were disclosed in the affected knee compartment with an equal frequency (n = 17). The size of the necrotic lesion varied among different stages of the disease as follows: 6.8% to 15.7% (stage I); 6.5% to 59.3% (stage II); 23.5% to 61.3% (stage III); and 34.3% to 75% (stage IV). The extent of involvement was greater in stage II than that in stage I (P < 0.001) and in stage IV than that in stage III (P < 0.05), whereas the extent of involvement in stage III was not significantly greater than that in stage II (P > 0.05). Conclusions: The MR imaging characteristics of osteonecrosis of the tibial plateau are variable. The association of osteonecrosis at this site with meniscal tears and cartilage abnormalities has important implications for pathogenesis of the disease as it relates to physical stress. Quantification of the lesion size provides precise information for optimal staging of the disease. From the *Department of Radiology, University of California; †Veterans Affairs Medical Center, San Diego, CA; ‡Department of Pathology, and §Department of Orthopedic Surgery, University of Athens, Athens, Greece. Received for publication May 13, 2009; accepted May 29, 2009. Reprints: Daphne J. Theodorou, MD, 13 Papadopoulos St, Ioannina, 45444, Greece (e-mail: email@example.com and firstname.lastname@example.org). © 2010 Lippincott Williams & Wilkins, Inc.