Skip Navigation LinksHome > March/April 2009 - Volume 33 - Issue 2 > Diffusion Tensor Imaging Abnormalities in Patients With Mild...
Journal of Computer Assisted Tomography:
doi: 10.1097/RCT.0b013e31817579d1
Neuroradiology: Original Article

Diffusion Tensor Imaging Abnormalities in Patients With Mild Traumatic Brain Injury and Neurocognitive Impairment

Lo, Calvin MD; Shifteh, Keivan MD; Gold, Tamar BA; Bello, Jacqueline A. MD; Lipton, Michael L. MD, PhD

Collapse Box


Objective: To determine if diffusion tensor imaging can differentiate patients with chronic cognitive impairment after mild traumatic brain injury (TBI) from normal controls.

Methods: Ten patients with persistent cognitive impairment after mild TBI were evaluated at least 2 years after injury. Fractional anisotropy (FA) and apparent diffusion coefficient (ADC) were measured at white matter regions susceptible to axonal injury after TBI. Comparison was made to 10 normal controls.

Results: Fractional anisotropy was significantly lower (4.5%; P = 0.01) and ADC higher (7.1%; P = 0.04) in patients at the left side of the genu of the corpus callosum. The mild TBI group also demonstrated a significant increase in FA within the posterior limb of the internal capsule bilaterally (left, 5.1%; P = 0.03; right, 1.9%; P = 0.04).

Conclusions: These results demonstrate low FA and high ADC in the genu of the corpus callosum of mild TBI patients with persistent cognitive impairment, suggesting that permanent white matter ultrastructural damage occurs in mild TBI, and that such damage may be associated with persistent cognitive disability. Further longitudinal studies are warranted to elucidate the full importance of the findings.

Copyright © 2009 Wolters Kluwer Health, Inc. All rights reserved.



Article Tools


Article Level Metrics

Search for Similar Articles
You may search for similar articles that contain these same keywords or you may modify the keyword list to augment your search.