The purpose of this review is to illustrate, with examples, the abdominal manifestations of neurofibromatosis type 1 (NF) on imaging, with emphasis on computed tomography. Mutations of the NF gene lead to abnormal tumor suppression. Consequently, NF is a complex disease, with patients having an increased prevalence of benign and malignant neoplasms throughout the body. We present cases of the most common abdominal presentations: neurofibroma, malignant peripheral nerve sheath tumor, pheochromocytoma, carcinoid, gastrointestinal stromal tumor, and seminoma.
From the *Department of Radiology, University Hospitals of Leicester NHS Trust, Leicester General Hospital, Leicester; †Department of Radiology, University Hospitals of Leicester NHS Trust, Glenfield Hospital, Groby Road, Leicester United Kingdom; and ‡Department of Radiology, Indiana University Hospital, Indianapolis, IN.
Received for publication October 27, 2006; accepted February 7, 2007.
Reprints: Nicola Hartley, MBChB, MRCS, Department of Radiology, University Hospitals of Leicester NHS Trust, Leicester General Hospital, Gwendolen Road, Leicester LE54PW, United Kingdom (e-mail: firstname.lastname@example.org).