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Diffusion Tensor MR Imaging in Pediatric Head Trauma

Akpinar, Erhan MD*†; Koroglu, Mert MD‡; Ptak, Thomas MD*

Journal of Computer Assisted Tomography:
doi: 10.1097/RCT.0b013e318033df1a
Neuroradiology: Original Article
Abstract

Purpose: We propose to investigate the fractional anisotropy (FA) values in pediatric patients with closed head trauma and correlate them with the initial Glasgow Coma Scale (GCS).

Materials and Methods: A retrospective evaluation of 24 pediatric patients (15 men, 9 women; mean age, 13 years; range, 2-18 years) who underwent both unenhanced head computed tomography and cerebral magnetic resonance imaging (MRI), including the tensor diffusion sequence, within 30 days of the incident. Twenty-two atraumatic control patients (9 men, 13 women; mean age, 9 years; range, 4-17 years) were randomly selected from the records of the radiology department within the same period. Fractional anisotropy measurements were taken from each of 6 major white matter volumes. Data extracted from the record of each subject included GCS, initial head computed tomographic results, and length of hospital stay. Kruskal-Wallis and t tests were used for statistical evaluation.

Results: The mean acute score on the GCS was 9.7 ± 5. Mean duration of hospitalization days was 8.7 ± 10. Statistically significant differences in mean FA values between trauma and control subjects were noted in corpus callosum. Trauma patients with positive findings on MRI and with GCS less than 10 also had lower FA values than patients with GCS greater than 10 and patients who had normal MRI findings. There was a negative correlation between time to discharge and FA values.

Conclusions: In pediatric head trauma, MRI diffusion FA measurements can show abnormalities despite normal-appearing brain MRI findings. Larger investigations are required to verify the stability of correlations.

Author Information

From the *Division of Emergency Radiology, Massachusetts General Hospital, Harvard Medical School, Boston, MA; †Department of Radiology, Faculty of Medicine, Hacettepe University, Ankara; and ‡Department of Radiology, Faculty of Medicine, Suleyman Demirel University, Isparta, Turkey.

Received for publication November 15, 1006; accepted January 3, 2007.

Reprints: Erhan Akpinar, MD, Department of Radiology, Faculty of Medicine, Hacettpe University, Sihhiye/Ankara, Turkey (e-mail: erhan.akpinar@gmail.com).

Dr. Erhan Akpinar is supported in part by a grant from "Scientific and Technical Research Council of the Turkish Republic" in this study.

© 2007 Lippincott Williams & Wilkins, Inc.