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Multidetector-Row Computed Tomograpy of Focal Liver Lesions Treated by Radiofrequency Ablation: Spectrum of Findings at Long-term Follow-up

Filippone, Antonella MD; Iezzi, Roberto MD; Di Fabio, Francesca MD; Cianci, Roberta MD; Grassedonio, Emanuele MD; Storto, Maria Luigia MD

Journal of Computer Assisted Tomography: January/February 2007 - Volume 31 - Issue 1 - pp 42-52
doi: 10.1097/01.rct.0000232264.36178.1e
Abdominal Imaging: Original Article

Objective: To assess serial changes in liver tumors after percutaneous radiofrequency ablation at follow-up multidetector-row computed tomography.

Materials and Methods: Forty patients with 65 malignant lesions underwent multidetector-row computed tomography immediately, 1 month and every 3 months, up to a maximum of 15 months after radiofrequency ablation. The computed tomography (CT) appearance of the treated lesions (non-enhanced attenuation, enhancement pattern, shape and size) was assessed at each follow-up. The relationship between each CT finding and the treatment outcome was evaluated by χ2 test (P < 0.05).

Results: No significant differences were found in lesion shape and in non-enhanced CT attenuation between successfully and unsuccessfully treated lesions, whereas over time change of lesion size was significantly different. The no enhancement and nodular enhancement pattern prevalence was significantly (P < 0.0001) different between successfully and unsuccessfully treated lesions, whereas non-nodular enhancement pattern did not show any relationship with the treatment outcome.

Conclusions: Lesion size increase and nodular enhancement pattern resulted significantly related to the treatment failure.

From the Department of Clinical Sciences and Bioimages, Section of Radiology, University G. d'Annunzio, Chieti, Italy.

Received for publication February 24, 2006; accepted May 24, 2006.

Reprints: Antonella Filippone, MD, Department of Clinical Sciences and Bioimages, Section of Radiology, University G. d'Annunzio, Chieti, 66013 Chieti, Italy (e-mail: a.filippone@rad.unich.it).

© 2007 Lippincott Williams & Wilkins, Inc.