You could be reading the full-text of this article now if you...

If you have access to this article through your institution,
you can view this article in

Dynamic Subtraction Magnetic Resonance Imaging of Cirrhotic Liver: Assessment of High Signal Intensity Lesions on Nonenhanced T1-Weighted Images

Yu, Jeong-Sik MD*†; Kim, Young Hwan MD‡; Rofsky, Neil M MD*

Journal of Computer Assisted Tomography:
Original Article: Abdominal Imaging
Abstract

Purpose: The purpose of this work was to determine the technical feasibility and value of dynamic subtraction (postcontrast-precontrast) magnetic resonance (MR) imaging for the assessment of hyperintense lesions on precontrast T1-weighted images in the cirrhotic liver.

Methods: One hundred four hyperintense lesions on T1-weighted precontrast and arterial phase postcontrast images were subjected to analysis of their subtraction qualities depending on the lesion size, location and/or the degree of misregistration between the source images in 27 different MR imaging sets.

Results: The quality of subtraction images was always diagnostic for lesions larger than 2 cm in diameter (n = 8) but not diagnostic for 73% (40 of 55 lesions) of small subcentimetric lesions. Thirty-one subcapsular lesions always showed a variable degree of coregistration artifact. Only 3 of 35 lesions with a slice misregistration of 3 mm or more gave rise to subtraction images of diagnostic quality. For determining the contrast enhancement, the area under the receiver operating characteristic curve of 30 verified lesions was significantly larger (P < 0.001) for subtraction images than for conventional arterial phase images.

Conclusion: Depending on the lesion size and/or location or the degree of misregistration between the source images, dynamic subtraction MR imaging can be useful for the characterization of hyperintense lesions on precontrast T1-weighted imaging.

Author Information

From the *Department of Radiology, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA; †Department of Diagnostic Radiology, YongDong Severance Hospital, Yonsei University College of Medicine, Seoul, South Korea; and ‡Department of Radiology, University of Massachusetts Memorial University Campus, North Worcester, MA.

Received for publication November 4, 2004; accepted November 30, 2004.

Reprints: Jeong-Sik Yu, Department of Diagnostic Radiology, YongDong Severance Hospital, Yonsei University College of Medicine, 146-92 Dogok-Dong, Gangnam-Gu, Seoul 135-720, South Korea (e-mail: yjsrad97@yumc.yonsei.ac.kr).

© 2005 Lippincott Williams & Wilkins, Inc.