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Intracranial Fluid Dynamics in Normal and Hydrocephalic States: Systems Analysis With Phase-Contrast Magnetic Resonance Imaging

de Marco, Giovanni PHD*; Idy-Peretti, Ilana MD, PHD†; Didon-Poncelet, Anne MD‡; Baledent, Olivier PHD*; Onen, Fannie MD§; Feugeas, Marie Cécile Henry MD, PHD

Journal of Computer Assisted Tomography: March/April 2004 - Volume 28 - Issue 2 - pp 247-254
Neuroimaging

Objective: To present a novel magnetic resonance (MR) method of analysis of cerebrospinal fluid (CSF) flow dynamics.

Methods: Fifty-one subjects were explored with phase-contrast cine MR imaging. There were 36 volunteers, 9 patients with normal pressure hydrocephalus (NPH), and 6 patients with asymptomatic ventricular dilation (VD). The transfer function XFRA/CSF from the arterial pulse waves (APWs) and the CSF pulse waves (CSFPWs) and the transfer function XFRCSF/SS from the CSF pulse waves (CSFPWs) and the sagittal sinus pulse waves (SSPWs) were studied separately.

Results: There was a significant difference in the amplitude spectrum of the XFRA/CSF of patients with VD and volunteers (P < 0.05) and in that of patients with NPH and volunteers (P = 0.005). The amplitude of the fundamental frequency was higher in the NPH group than in the VD group (P = 0.02). In patients with NPH, the amplitude spectrum of XFRCSF/SS showed an attenuation of the pulse wave components that significantly differed from the observed amplification in healthy subjects (P = 0.009) and patients with VD (P = 0.012).

Conclusion: This systems analysis method could help to detect increased venous compliance in VD and decreased venous compliance in NPH.

From the *Department of Biophysics and Image Processing, Northern Hospital, and University of Picardie Jules Verne, Amiens, †Department of Nuclear Medicine, Lariboisiere University Hospital, Paris, ‡Department of Nuclear Medicine, Haguenau Hospital, Haguenau, and §Department of Gerontology, Bichat-Claude Bernard University Hospital, Paris, France; Department of Radiology, Bichat-Claude Bernard University Hospital, Paris, France.

Supported with a grant-in-aid from the regional institution Le Conseil Régional de Picardie and from the European institution Fonds Européens de Développement Régional.

Reprints: Dr Ilana Idy-Peretti, Department of Nuclear Medicine, Lariboisiere University Hospital, AP-HP, 2 rue Ambroise-Pare, 75475, Paris, France (e-mail: ilana.peretti@lrb.ap-hop-paris.fr1).

© 2004 Lippincott Williams & Wilkins, Inc.