Skip Navigation LinksHome > March/April 2004 - Volume 28 - Issue 2 > Intracranial Fluid Dynamics in Normal and Hydrocephalic Stat...
Journal of Computer Assisted Tomography:

Intracranial Fluid Dynamics in Normal and Hydrocephalic States: Systems Analysis With Phase-Contrast Magnetic Resonance Imaging

de Marco, Giovanni PHD*; Idy-Peretti, Ilana MD, PHD†; Didon-Poncelet, Anne MD‡; Baledent, Olivier PHD*; Onen, Fannie MD§; Feugeas, Marie Cécile Henry MD, PHD

Collapse Box


Objective: To present a novel magnetic resonance (MR) method of analysis of cerebrospinal fluid (CSF) flow dynamics.

Methods: Fifty-one subjects were explored with phase-contrast cine MR imaging. There were 36 volunteers, 9 patients with normal pressure hydrocephalus (NPH), and 6 patients with asymptomatic ventricular dilation (VD). The transfer function XFRA/CSF from the arterial pulse waves (APWs) and the CSF pulse waves (CSFPWs) and the transfer function XFRCSF/SS from the CSF pulse waves (CSFPWs) and the sagittal sinus pulse waves (SSPWs) were studied separately.

Results: There was a significant difference in the amplitude spectrum of the XFRA/CSF of patients with VD and volunteers (P < 0.05) and in that of patients with NPH and volunteers (P = 0.005). The amplitude of the fundamental frequency was higher in the NPH group than in the VD group (P = 0.02). In patients with NPH, the amplitude spectrum of XFRCSF/SS showed an attenuation of the pulse wave components that significantly differed from the observed amplification in healthy subjects (P = 0.009) and patients with VD (P = 0.012).

Conclusion: This systems analysis method could help to detect increased venous compliance in VD and decreased venous compliance in NPH.

© 2004 Lippincott Williams & Wilkins, Inc.



Article Tools


Article Level Metrics

Search for Similar Articles
You may search for similar articles that contain these same keywords or you may modify the keyword list to augment your search.