Institutional members access full text with Ovid®

Share this article on:

Does patient-prosthesis mismatch after aortic valve replacement affect survival and quality of life in elderly patients?.

Sportelli, Elena; Regesta, Tommaso; Salsano, Antonio; Ghione, Paola; Brega, Carlotta; Bezante, Gian Paolo; Passerone, Giancarlo; Santini, Francesco
Journal of Cardiovascular Medicine: Post Author Corrections: July 31, 2015
doi: 10.2459/JCM.0000000000000292
Original article: PDF Only

Background: To evaluate the impact of patient-prosthesis mismatch (PPM) on survival, functional status, and quality of life (QoL) after aortic valve replacement (AVR) with small prosthesis size in elderly patients.

Methods: Between January 2005 and December 2013, 152 patients with pure aortic stenosis, aged at least 75 years, underwent AVR, with a 19 or 21 mm prosthetic heart valve. PPM was defined as an indexed effective orifice area less than 0.85 cm2/m2. Median age was 82 years (range 75-93 years). Mean follow-up was 56 months (range 1-82 months) and was 98% complete. Late survival rate, New York Heart Association functional class, and QoL (RAND SF-36) were assessed.

Results: Overall, PPM was found in 78 patients (53.8%). Among them, 42 patients (29%) had an indexed effective orifice area less than 0.75 cm2/m2 and 17 less than 0.65 cm2/m2 (11.7%). Overall survival at 5 years was 78 +/- 4.5% and was not influenced by PPM (P = NS). The mean New York Heart Association class for long-term survivors with PPM improved from 3.0 to 1.7 (P < 0.001). QoL (physical functioning 45.18 +/- 11.35, energy/fatigue 49.36 +/- 8.64, emotional well being 58.84 +/- 15.44, social functioning 61.29 +/- 6.15) was similar to that of no-PPM patients (P = NS).

Conclusion: PPM after AVR does not affect survival, functional status, and QoL in patients aged at least 75 years. Surgical procedures, often time-consuming, contemplated to prevent PPM, may therefore be not justified in this patient subgroup.

Copyright (C) 2015 Wolters Kluwer Health, Inc. All rights reserved.