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NSAIDs and cardiovascular risk

Marsico, Fabio; Paolillo, Stefania; Filardi, Pasquale P.

Journal of Cardiovascular Medicine: January 2017 - Volume 18 - Issue - p e40–e43
doi: 10.2459/JCM.0000000000000443
SPECIAL ISSUE GUEST EDITORS: Francesco Prati, MD Mario Albertucci, MD

NSAIDs are the most largely used class of drugs in the world, due to their large use in many diseases, in particular for the systemic inflammatory diseases. Nevertheless, today NSAIDs are less used for some of these diseases, due to several side-effects correlated to these drugs. The antiinflammatory mechanism of NSAIDs consist in the inibhition of two forms of cyclooxygenase, namely COX-1 (its block contributes to an antiplatelet effect) and COX-2 (its block has a greater antiinflammatory, antipyretic and analgesic effect). The COX-2 inhibition might reduce the risk of gastrointestinal toxicity, but several studies have shown the cardiovascular side effects of this inhibition. Mechanisms of the cardiovascular side effects are controversial yet, so the aim of this document is to review side-effects profile of NSAIDs and, specifically, to investigate cardiovascular consequences of NSAIDs use in clinical practice.

Department of Advanced Biomedical Sciences, University of Naples Federico II, Naples, Italy

Correspondence to Pasquale P. Filardi, MD, PhD, Department of Advanced Biomedical Sciences, University of Naples Federico II, Via Pansini, 5, I-80131 Naples, Italy Tel: +39 081 746 22 24; fax: +39 081 746 22 24; e-mail:

Received 16 June, 2016

Accepted 8 July, 2016

© 2017 Italian Federation of Cardiology. All rights reserved.