Journal of Cardiovascular Medicine

Skip Navigation LinksHome > April 2010 - Volume 11 - Issue 4 > Echocardiographic abnormalities and their correlation with b...
Journal of Cardiovascular Medicine:
doi: 10.2459/JCM.0b013e3283347df3
Original articles

Echocardiographic abnormalities and their correlation with bronchiectasis score in primary antibody deficiencies

Zeinaloo, Ali Akbar; Aghamohammadi, Asghar; Shabanian, Reza; Salavati, Ali; Abdollahzade, Sina; Rezaei, Nima; Alizadeh, Hooman; Zanjani, Keyhan Sayadpour; Kiani, Abdolrazagh

Collapse Box


Background: Primary antibody deficiencies are characterized by defective antibody production and recurrent infections. Patients usually present with recurrent respiratory tract infections with consequent chronic pulmonary damage and bronchiectasis, which could potentially influence cardiac function. Our aim was to assess noninvasively the cardiac complications due to pulmonary disease in patients with primary antibody deficiency.

Methods: A cross-sectional series of patients with primary antibody deficiency syndromes from our referral immunology center were recruited. Individuals undergoing high-resolution computed tomography (HRCT) and transthoracic echocardiography were reviewed.

Results: Thirty primary immunodeficient patients aged 5–55 years of age (21 males and 9 females) were enrolled in this study. Half of the patients (50%) were found to have bronchiectasis in HRCT imaging. In echocardiographic examination, 20 patients (67%) had at least one abnormality; among which pulmonary hypertension was the most common (33%). Patients with bronchiectasis had higher pulmonary artery pressures and HRCT bronchiectasis score was strongly correlated with pulmonary artery pressure (regression R = 0.59, P value = 0.001).

Conclusion: Echocardiographic evaluation of right ventricular function and noninvasive estimation of pulmonary artery pressure could have an important diagnostic role in the follow-up and therapeutic management of patients with primary immune deficiency.

© 2010 Italian Federation of Cardiology. All rights reserved.


Article Tools


Article Level Metrics

Search for Similar Articles
You may search for similar articles that contain these same keywords or you may modify the keyword list to augment your search.