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Developing a Clinically Representative Model of Periprosthetic Joint Infection

Carli, Alberto V. MD, MSc, FRCSC; Ross, F. Patrick PhD; Bhimani, Samrath J. BS; Nodzo, Scott R. MD; Bostrom, Mathias P.G. MD

Journal of Bone & Joint Surgery - American Volume: 5 October 2016 - Volume 98 - Issue 19 - p 1666–1676
doi: 10.2106/JBJS.15.01432
Current Concepts Review
Supplementary Content
Disclosures

The poor treatment outcomes for periprosthetic joint infection (PJI) reflect the limited understanding that currently exists regarding the pathogenesis of this devastating clinical problem.

Current animal models of PJI are limited in their translational nature primarily because of their inability to recreate the periprosthetic environment.

A greater mechanistic understanding of the musculoskeletal and immune systems of small animals, such as mice and rats, provides a more robust platform for modeling and examining the pathogenesis of PJI.

A clinically representative PJI model must involve an implant that recreates the periprosthetic space and be amenable to methodologies that identify implant biofilm as well as quantify the peri-implant bacterial load.

1Hospital for Special Surgery, New York, NY

E-mail address for A.V. Carli: CarliA@hss.edu

E-mail address for F.P. Ross: RossF@hss.edu

E-mail address for S.J. Bhimani: BhimaniS@hss.edu

E-mail address for S.R. Nodzo: NodzoS@hss.edu

E-mail address for M.P.G. Bostrom: BostromM@hss.edu

Copyright 2016 by The Journal of Bone and Joint Surgery, Incorporated
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