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Primary Epiphyseal or Apophyseal Subacute Osteomyelitis in the Pediatric Population: A Report of Fourteen Cases and a Systematic Review of the Literature

Ceroni, Dimitri MD; Belaieff, Wilson MD; Cherkaoui, Abdessalam MD, PhD; Lascombes, Pierre MD, PhD; Schrenzel, Jacques MD, PhD; de Coulon, Geraldo MD; Dubois-Ferrière, Victor MD; Dayer, Romain MD

Journal of Bone & Joint Surgery - American Volume: 17 September 2014 - Volume 96 - Issue 18 - p 1570–1575
doi: 10.2106/JBJS.M.00791
Evidence-Based Orthopaedics
Supplementary Content
Disclosures

Background: Primary epiphyseal or apophyseal subacute osteomyelitis (PEASAO) is a rare condition that typically has mild symptoms and lack of a systemic reaction, according to opinions, case reports, and case series. We reviewed fourteen consecutive cases of PEASAO treated at our institution over a thirteen-year period to characterize this disorder.

Methods: We retrospectively reviewed the medical records of all children and adolescents who had been surgically managed for PEASAO at our institution from January 2000 to December 2012. A systematic review of the literature was also performed to identify trends in causative organisms and formulate evidence-based recommendations for diagnosis and treatment.

Results: Fourteen children (median age, 27.8 months) with PEASAO were included in the study. Fever (rectal temperature, >38°C) was present at admission in two children, C-reactive protein was within the normal range (<10 mg/dL) in eleven, the erythrocyte sedimentation rate was >20 mm/hr in eight, and the white blood-cell count was normal in all. The pathogen was not identified on blood cultures in any child and was identified on classical cultures of bone samples in only one. Use of PCR (polymerase chain reaction) assays allowed the pathogen to be identified in an additional eight children. The pathogen was Kingella kingae in eight and methicillin-sensitive Staphylococcus aureus in one.

Discussion: The use of organism-specific real-time PCR assays markedly improves the detection rate of the pathogen responsible for PEASAO, and K. kingae is the most commonly detected pathogen. The literature highlights a biphasic age distribution of PEASAO in children. The infantile form affects children from one to less than four years of age, accounting for approximately 75% of all PEASAO cases. The second form, in older children, is more likely to be associated with fever and systemic symptoms. The femur and the tibia are the most commonly affected long bones. Laboratory data are usually noncontributory for diagnosing PEASAO, and blood cultures are often sterile. Although K. kingae is the most commonly detected microorganism in children less than four years of age, S. aureus is responsible for most PEASAO in older children. Antibiotic treatment is usually sufficient to eradicate the pathogen.

1Pediatric Orthopedic Service (D.C., W.B., P.L., G.d.C., V.D.-F., and R.D.) and Clinical Microbiology Laboratory, Service of Infectious Diseases (A.C. and J.S.), University Hospitals of Geneva, 6 rue Willy Donzé, CH-1211 Geneva 14, Switzerland. E-mail address for D. Ceroni: dimitri.ceroni@hcuge.ch

Copyright 2014 by The Journal of Bone and Joint Surgery, Incorporated
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