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The Effect of Immobilization on the Native and Repaired Tendon-to-Bone Interface

Hettrich, C.M. MD, MPH; Gasinu, S. MD; Beamer, B.S. MD; Fox, A. MS; Ying, O.; Deng, X.H. MD; Rodeo, S.A. MD

Journal of Bone & Joint Surgery - American Volume: 15 May 2013 - Volume 95 - Issue 10 - p 925–930
doi: 10.2106/JBJS.K.01329
Scientific Articles
Supplementary Content
Disclosures

Background: Little is known of the cellular events that occur in native or repaired tendons as a result of immobilization after injury. To examine this issue, we compared (1) native tendons without immobilization, (2) native tendons with immobilization, and (3) surgically repaired tendons with immobilization.

Methods: Eighty-one rats underwent either patellar tendon repair followed by immobilization or immobilization of the native tendon without repair. A custom external fixation device was used for immobilization. The tendon-bone insertion site was evaluated after two and four weeks of immobilization with use of histologic, radiographic, and biomechanical analyses.

Results: Immobilization of the native tendon led to a significant decrease in the load to failure (p < 0.01) and stiffness (p < 0.05) compared with the native tendon at both two and four weeks. The repaired/immobilized group had a significantly lower load to failure at two weeks compared with the native/immobilized group (p < 0.05); however, by four weeks, the repaired group was significantly stronger (p < 0.01). Micro-computerized tomography demonstrated no significant differences in bone microstructure at two weeks but demonstrated increased bone mineral density and bone volume fraction in the repaired/immobilized group at four weeks. There was significantly more MMP-13 (matrix metalloproteinase-13) staining in the native/immobilized specimens compared with the native specimens at both time points (p < 0.01).

Conclusions: Immobilization had a significant detrimental effect on the bone-tendon complex. At two weeks there was a significant decrease in the mechanical properties of the native tendon, but the immobilized, native tendon remained significantly stronger than the repaired and immobilized tendon. However, four weeks of immobilization led to a significant loss of strength of the bone-tendon complex in the native tendon, such that it was significantly weaker than the repaired and immobilized tendon. Surgeons who manage patients with immobilization should be aware of the changes at the bone-tendon complex.

Clinical Relevance: Immobilization may have negative effects on the native bone-tendon complex.

12701 Prairie Meadow Drive, Iowa City, IA 52242. E-mail address: carolyn-hettrich@uiowa.edu

2Hospital for Special Surgery, 535 East 70th Street, New York, NY 10021

Copyright 2013 by The Journal of Bone and Joint Surgery, Incorporated
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