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Bilateral Total Knee Replacement: Staging and Pulmonary Embolism

Barrett, Jane MSc; Baron, John A. MD, MSc; Losina, Elena PhD; Wright, John MD; Mahomed, Nizar N. MD, ScD; Katz, Jeffrey N. MD, MS

Journal of Bone & Joint Surgery - American Volume: October 2006 - Volume 88 - Issue 10 - p 2146–2151
doi: 10.2106/JBJS.E.01323
Scientific Articles

Background: When a bilateral total knee replacement is indicated, it is not clear whether it is preferable to operate on both knees during the same hospitalization (simultaneously) or to stage the procedures in two separate hospital stays. A greater risk of pulmonary embolism after simultaneous total knee replacement has been reported by some authors, but little national data are available.

Methods: We reviewed the records of 122,385 United States Medicare enrollees who had had a total knee replacement in 2000. We noted whether they had had a unilateral procedure or two procedures and, if they had had two procedures, whether both had been done during the same hospitalization or whether the operations had been performed during two separate hospital stays. Age, sex, race, residence, Medicaid eligibility (a proxy for low income), and the Charlson comorbidity score were documented for each patient as were the total numbers of total knee replacements performed in the year 2000 by the hospital and the surgeon. The probability of a symptomatic pulmonary embolism developing in the first three months after surgery was calculated for the simultaneous, staged, and unilateral procedures.

Results: Simultaneous procedures were much more likely to be performed in high-volume hospitals and by high-volume surgeons than were staged procedures. Men had proportionately more simultaneous procedures than did women. Hospitals in the northeastern United States were the most likely to perform simultaneous procedures. A pulmonary embolism developed in the first three months in 0.81% of the patients who had had a single procedure compared with 1.44% of the patients who had undergone a simultaneous procedure (adjusted hazard ratio 1.81; 95% confidence interval, 1.49, 2.20).

Conclusions: The systematic differences in patient gender, hospital and surgeon volume, and geographic region between those who undergo simultaneous total knee replacements and those who undergo staged procedures should be borne in mind when outcomes are being compared. The adjusted risk of pulmonary embolism is about 80% higher in the three months after a simultaneous procedure than in the three months after a single procedure, which suggests that the sum of the risks associated with the two operations of a staged procedure may equal or exceed the risk of simultaneous total knee replacement.

Level of Evidence: Therapeutic Level III. See Instructions to Authors for a complete description of levels of evidence.

1 Departments of Medicine (J.A.B.) and Community and Family Medicine (J.B. and J.A.B.), and Section of Biostatistics and Epidemiology (J.B. and J.A.B.), Dartmouth Medical School, 46 Centerra Parkway, Evergreen Building, Suite 300, Lebanon, NH 03766. E-mail address for J. Barrett:

2 Department of Biostatistics, Boston University School of Public Health, 715 Albany Street, TE421, Boston, MA 02118

3 Section of Clinical Sciences, Division of Rheumatology, Immunology and Allergy (J.N.K.), and Department of Orthopaedic Surgery (J.W. and J.N.K.) Brigham and Women's Hospital, 75 Francis Street, Boston, MA 02115

4 Musculoskeletal Health and Arthritis Program, Toronto Western Hospital, University Health Network, University of Toronto, 399 Bathurst Street, Toronto, ON M5T 2S8, Canada

Copyright 2006 by The Journal of Bone and Joint Surgery, Incorporated
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