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The Use of Alendronate to Prevent Early Collapse of the Femoral Head in Patients with Nontraumatic Osteonecrosis: A Randomized Clinical Study

Lai, Kuo-An MD; Shen, Wun-Jer MD; Yang, Chyun-Yu MD; Shao, Chung-Jung MD; Hsu, Jui-Ting PhD; Lin, Ruey-Mo MD

Journal of Bone & Joint Surgery - American Volume: October 2005 - Volume 87 - Issue 10 - p 2155–2159
doi: 10.2106/JBJS.D.02959
Scientific Articles
Supplementary Content

Background: Osteonecrosis of the femoral head is the most common diagnosis leading to total hip arthroplasty in young adults. Joint-preserving treatment options have been mainly surgical, with inconsistent results. Alendronate (a bisphosphonate agent) has been shown to lower the prevalence of vertebral compression fractures and could potentially retard the collapse of an osteonecrotic femoral head. The purpose of this study was to test the effect of alendronate in preventing early collapse of the femoral head in patients with nontraumatic osteonecrosis.

Methods: Forty patients with Steinberg stage-II or III nontraumatic osteonecrosis of the femoral head and a necrotic area of >30% (class C) were randomly divided into alendronate and control groups of twenty patients each. Patients in the alendronate group took 70 mg of alendronate orally per week for twenty-five weeks, while the patients in the control group did not receive this medication or a placebo. The patients were observed for a minimum of twenty-four months. Harris hip scores, plain radiographs, and magnetic resonance imaging scans were obtained.

Results: During the study period, only two of twenty-nine femoral heads in the alendronate group collapsed, whereas nineteen of twenty-five femoral heads in the control group collapsed (p < 0.001). One hip in the alendronate group underwent total hip arthroplasty, whereas sixteen hips in the control group underwent total hip arthroplasty (p < 0.001).

Conclusions: Alendronate appeared to prevent early collapse of the femoral head in the hips with Steinberg stage-II or IIIC nontraumatic osteonecrosis. A longer duration of follow-up is needed to confirm whether alendronate prevents or only retards collapse.

Level of Evidence: Therapeutic Level I. See Instructions to Authors for a complete description of levels of evidence.

1 Orthopaedic Department (K.-A.L., C.-Y.Y., C.-J.S., and R.-M.L.) and the Institute of Biomedical Engineering (J.-T.H.), National Cheng Kung University Medical Center, No. 138 Shen-Li Road, Tainan, Taiwan. E-mail address for K.-A. Lai: E-mail address for J.-T. Hsu:

2 Po-Cheng Orthopaedic Institute, 100 Po-Ai 2nd Road, Kaohsiung 81357, Taiwan

Copyright 2005 by The Journal of Bone and Joint Surgery, Incorporated
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