This is a follow-up report of a patient who was originally reported because of the associations of chronic renal failure and acidosis with elastic-staining fibers in tendon. The patient lived another twenty months, with acidosis only partly corrected; extensive but inconstant calcification developed in subcutaneous tissues and tendons. At autopsy he also had calcification in viscera, usually in areas of positive staining to elastic stains or periodic acid-Schiff stain, or both.
Some aspects of soft-tissue calcification are reviewed, and the suggestion offered that prolonged acidosis can lead to changes in tissue protein which favor calcium deposition.
Copyright 1967 by The Journal of Bone and Joint Surgery, Incorporated