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Sulphate Metabolism in Cartilage: II. S35-Sulphate Uptake and Total Sulphate in Cartilage Slices.

Coelho, Rose Robyns; Chrisman, O. Donald
Journal of Bone & Joint Surgery - American Volume: January 1960
Archive: PDF Only

Comparison of uptake of S35 sulphate and total sulphur sulphate in cartilage strips incubated in Krebs-Ringer's solution indicates that over-all breakdown of chondroitin sulphate is taking place despite vigorous uptake of S35.

S35 uptake is inhibited by cyanide and iodoacetate; however, cyanide protects against total sulphate sulphur loss while iodoacetate has no effect or may even increase the loss.

The existence of a cyanide-sensitive enzyme responsible for one of the early steps in cartilage breakdown is suggested.

Copyright 1960 by The Journal of Bone and Joint Surgery, Incorporated

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