Tobacco use in adolescence remains at unacceptable levels. Increasing teen knowledge about the dangers of smoking appears to be insufficient in changing adolescent attitudes regarding the use of tobacco. To incite change and increase their effectiveness, adult smoking cessation programs need to be tailored to adolescents. Ultimately, intrapersonal, interpersonal, and environmental factors that underlie tobacco use and smoking behaviors in adolescents must be identified. The nurse’s role is both in identification of the adolescent smoker and assessment of the smoking behavior. Future directions in nursing practice, nursing education, and research surrounding tobacco use in youth are discussed.