The Agency for Healthcare Research and Quality's (Fiore et al., 2008) clinical guidelines on smoking cessation identified seven medications as first‐line drugs which have been shown to promote long‐term smoking cessation efforts. These pharmacological agents include five types of nicotine replacement therapies and two specific drugs, Buproprion SR and Varenicline. Key issues that health care professionals should address when caring for individuals who are dependent on tobacco are discussed. Barriers, such as the attitudes and knowledge of the persons who smoke and health care professionals, that impede individuals’ use of medications within their plan of smoking cessation are addressed. Special attention is given to the increase in suicide potential during the process of quitting. The need for nurses and other health care professionals to pursue research to identify the most effective ways of educating themselves to promote smoking cessation with males and females from adolescence through old age, including those with mental health and addiction disorders, is emphasized.