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Mortality in HIV-Infected and Uninfected Children of HIV-Infected and Uninfected Mothers in Rural Uganda

Brahmbhatt, Heena PhD*; Kigozi, Godfrey MD†; Wabwire-Mangen, Fred PhD‡; Serwadda, David MD§; Lutalo, Tom MSc†; Nalugoda, Fred MD†; Sewankambo, Nelson MD∥; Kiduggavu, Mohamed MD†; Wawer, Maria MD¶; Gray, Ronald MD*

JAIDS Journal of Acquired Immune Deficiency Syndromes: 1 April 2006 - Volume 41 - Issue 4 - pp 504-508
doi: 10.1097/01.qai.0000188122.15493.0a
Epidemiology and Social Science

Objective: To estimate 2-year mortality rates in HIV-1-infected and uninfected infants born to HIV+ and HIV mothers.

Methods: Data are from a prospective study in rural Rakai District, Uganda. Infant HIV status (determined by polymerase chain reaction) was evaluated at 1 to 6 weeks postpartum and during breast-feeding, and maternal HIV viral load and CD4 levels were measured at the postpartum visit. Multivariate Cox proportional hazards models and Kaplan-Meier survival analysis were used to assess survival of infants by maternal and infant HIV status and by quartiles of viral load. Log-rank tests were used to test the equality of survival functions.

Results: Of the 4604 pregnant women, 16.9% were HIV+, and the proportion of children infected was 20.9%. Median survival of HIV-infected infants was 23 months. Two-year child mortality rates were 128 of 1000 children born to HIV mothers, 165.5 of 1000 uninfected children born to HIV+ mothers, and 540.1 of 1000 HIV-infected children (P < 0.0001). Compared with children of HIV mothers, the hazard of child mortality was 2.04 (P < 0.001) if the mother was HIV+and 3.78 (P < 0.001) if the infant was also infected. In the adjusted model, the highest quartiles of log10 HIV viral load in infants and mothers were associated with significantly increased hazard of child mortality (hazard ratio [HR] = 8.54 and HR = 2.50, respectively). Maternal CD4 counts <200 cells/mL were also significant predictors of child mortality (HR = 2.61). A total of 67.6% of HIV-infected children with viral loads above the median died by the age of 2 years and are in need of early antiretroviral therapy (ART).

Conclusions: More than half of HIV-infected infants died at less than 2 years of age. Therefore, ART may need to be initiated earlier in HIV-infected African children.

From the *Department of Population and Family Health Sciences, The Johns Hopkins University, Bloomberg School of Public Health, Baltimore, MD; †Rakai Project, Uganda Virus Research Institute, Entebbe, Uganda; ‡Institute of Public Health, Makerere University, Kampala, Uganda; §School of Public Health, Makerere University, Kampala, Uganda; ∥School of Medicine, Makerere University, Kampala, Uganda; and ¶Heilbrun Center for Population and Family Health, Columbia University, Joseph L. Mailman School of Public Health, New York, NY.

Received for publication December 3, 2005; accepted September 16, 2005.

Supported by grants RO1 AI34826 and RO1 AI3426S from the National Institute of Allergy and Infectious Diseases, grant 5P30HD06826 from the National Institute of Child Health and Development, grant 5D43TW00010 from the Fogarty Foundation, the US National Institutes of Health, and the World Bank Sexually Transmitted Infection Project, Uganda.

Reprints: Heena Brahmbhatt, Department of Population and Family Health Sciences, The Johns Hopkins University, Bloomberg School of Public Health, Suite 4030, 615 North Wolfe Street, Baltimore, MD 21205 (e-mail: hbrahmbh@jhsph.edu).

© 2006 Lippincott Williams & Wilkins, Inc.