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Carotid Intima-Media Thickness in Heavily Pretreated HIV-Infected Patients

Chironi, Gilles; Escaut, Lelia; Gariepy, Jerome; Cogny, Anne; Monsuez, Jean-Jacques; Levenson, Jaime; Simon, Alain; Vittecoq, Daniel

JAIDS Journal of Acquired Immune Deficiency Syndromes: 15 April 2003 - Volume 32 - Issue 5 - pp 490-493
CLINICAL SCIENCE: Brief Report

The authors used ultrasonography to measure carotid artery intima-media thickness (IMT) in 36 HIV-infected patients taking highly active antiretroviral therapy (cases) and in two control groups without (control group 1) or with (control group 2) blood lipid and glucose disturbances similar to those of the patients. Case IMT values were 8% higher than control group 1 IMT values (p < .05) but not different from control group 2 IMT values. Positive independent associations of IMT with the total-to-HDL cholesterol ratio and waist circumference existed for cases (p < .05) but not for controls. Case IMT did not correlate with parameters of HIV infection and antiretroviral treatment. This case-control study suggests that lipid disturbances, mainly hypoHDLemia, may be involved in the early atherosclerotic process in HIV-infected patients.

*Centre de Médecine Préventive Cardiovasculaire and Unité CNRS UMR7131, Hôpital Broussais, Paris, †Service des Maladies Infectieuses et Tropicales, Hôpital Paul Brousse, Villejuif, and ‡Service de Biochimie, Hôpital Europeen Georges Pompidou, Paris, France

Address correspondence and reprint requests to Professor Alain Simon, Centre de Médecine Préventive Cardiovasculaire, Hôpital Broussais, 96, rue Didot, 75674 Paris Cedex 14, France. E-mail: alain.simon@brs.ap-hop-paris.fr

Manuscript received July 31, 2002; accepted February 5, 2003.

Copyright © 2003 Wolters Kluwer Health, Inc. All rights reserved.