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Effect of GB Virus C/Hepatitis G Virus Coinfection on the Course of HIV Infection in Hemophilia Patients in Japan

Toyoda, Hidenori; Fukuda, Yoshihide; Hayakawa, Tetsuo; Takamatsu, Junki; Saito, Hidehiko
JAIDS Journal of Acquired Immune Deficiency Syndromes: March 1st, 1998

Objective:A novel virus, GB virus C (GBV-C)/hepatitis G virus (HGV), has been isolated. This virus is parenterally transmissible, but its effect on various diseases remains to be disclosed. We investigated the effect of GBV-C/HGV coinfection on the course of HIV infection.

Methods:GBV-C/HGV RNA was measured by nested reverse transcription polymerase chain reaction (RT-PCR) in 41 HIV-infected hemophilia patients in Japan. Patient characteristics, HIV RNA concentrations, and rates of progression to AIDS and to death were compared in patients with and without GBV-C/HGV coinfection. HIV RNA was quantified by the Amplicor HIV Monitor test (Roche Molecular Systems, Somerville, NJ, U.S.A.), and progression to AIDS and to death was analyzed using Kaplan-Meier plots.

Results:GBV-C/HGV infection was present in 11 of 41 of patients (26.8%). Mean HIV RNA concentration was lower in patients with GBV-C/HGV coinfection (3.52 ± 4.81 × 104 copies/ml) than in patients without coinfection (5.76 ± 14.78 × 104 copies/ml) and progression to AIDS and to death were slower in patients with GBV-C/HGV coinfection than patients without it, although the differences were not statistically significant.

Conclusion:In Japanese hemophilia patients, coinfection with GBV-C/HGV does not have an adverse effect on the course of HIV infection.

Address correspondence and reprint requests to Hidenori Toyoda, Second Department of Internal Medicine, Nagoya University, School of Medicine, 65 Tsuruma-cho, Showa-ku, Nagoya, 466 Japan.

Manuscript received June 4, 1997; accepted October 13, 1997.

© Lippincott-Raven Publishers.