Dr. Paul Volberding, Clinical Science:
Antiretroviral therapy has continued to evolve from the first introduction of patent combined drug regimens in the mid-1990s. Improvements in treatment outcome as witnessed by the important MACS Cohort are fascinating and captured nicely in this paper. Over time, treatment is more easily tolerated supporting better adherence and less regimen changes or switching. It will be interesting to see if even newer drugs continue this historic trend.
Read suggested article here: Increases in Duration of First HAART over Time (1996-2009) and Associated Factors in the Multicenter AIDS Cohort Study.
Dr. William Blattner, Epidemiology and Prevention:
As the US National AIDS strategy targets the low viral suppression treatment cascade rate, this study from Montaner and colleague in British Columbia where universal health care is available still reports a refractory 20% unsuppressed linked to social factors: poverty and interlocking injection drug abuse – pointing to the need for integrated medical, psychiatric and social services.
Read suggested article here: Trends in plasma HIV-RNA suppression and antiretroviral resistance in British Columbia, 1997-2010
In a related study early age of initiation of female sex work reinforces the role of substance abuse and social isolation fueling high risk sexual behavior that continues to drive the epidemic.
Read suggested article here: Early sex work initiation independently elevates odds of HIV infection and police arrest among adult sex workers in a Canadian setting
Adimora and colleagues, digging deeply into the drivers of the US rising epidemic among southern African American, especially understudied women report high rates of concurrent sexual partnerships and rapid turnover in new partner initiation linked to complex social patterns driving the epidemic in this community.
Read suggested article here: Characteristics of multiple and concurrent partnerships among women at high risk for HIV infection