JAIDS Journal of Acquired Immune Deficiency Syndromes:
Brief Report: Epidemiology and Prevention
Dose-Response Associations Between Number and Frequency of Substance Use and High-Risk Sexual Behaviors Among HIV-Negative Substance-Using Men Who Have Sex With Men (SUMSM) in San Francisco
Santos, Glenn-Milo MPH*,†; Coffin, Phillip O. MD, MIA*,‡; Das, Moupali MD, MPH*,‡; Matheson, Tim PhD*; DeMicco, Erin MPH*; Raiford, Jerris L. PhD‖; Vittinghoff, Eric PhD†; Dilley, James W. MD§; Colfax, Grant MD*,‡; Herbst, Jeffrey H. PhD‖
*San Francisco Department of Public Health, San Francisco, CA;
†Department of Epidemiology and Biostatistics,
‡Division of HIV/AIDS, and
§Department of Psychiatry, University of California San Francisco, San Francisco, CA; and
‖Division of HIV/AIDS Prevention, National Center for HIV/AIDS Viral Hepatitis, STD, and TB Prevention, Centers for Disease Control, Atlanta, GA.
Correspondence to: Glenn-Milo Santos, MPH, San Francisco Department of Public Health, 25 Van Ness Avenue, Suite 500, San Francisco, CA 94102 (e-mail: firstname.lastname@example.org).
Supported by the Centers for Disease Control and Prevention, under cooperative agreement UR6PS000684 to Public Health Foundation Enterprises, City of Industry, CA.
The authors have no conflicts of interest to disclose.
The findings and conclusions in this report are those of the authors and do not necessarily represent the views of the US Centers for Disease Control and Prevention.
Received January 29, 2013
Accepted March 22, 2013
Abstract: We evaluated the relationship between frequency and number of substances used and HIV risk [ie, serodiscordant unprotected anal intercourse (SDUAI)] among 3173 HIV-negative substance-using MSM. Compared with nonusers, the adjusted odds ratio (AOR) for SDUAI among episodic and at least weekly users, respectively, was 3.31 [95% confidence interval (CI), 2.55 to 4.28] and 5.46 (95% CI, 3.80 to 7.84) for methamphetamine, 1.86 (95% CI, 1.51 to 2.29) and 3.13 (95% CI, 2.12 to 4.63) for cocaine, and 2.08 (95% CI, 1.68 to 2.56) and 2.54 (95% CI, 1.85 to 3.48) for poppers. Heavy alcohol drinkers reported more SDUAI than moderate drinkers [AOR, 1.90 (95% CI, 1.43 to 2.51)]. Compared with nonusers, AORs for using 1, 2, and ≥3 substances were 16.81 (95% CI, 12.25 to 23.08), 27.31 (95% CI, 18.93 to 39.39), and 46.38 (95% CI, 30.65 to 70.19), respectively. High-risk sexual behaviors were strongly associated with frequency and number of substances used.
Men who have sex with men (MSM) account for roughly 4% of the US male population, yet comprised 79% of all HIV diagnoses among men in 2011.1,2 Substance use—including predominantly noninjection substances such as alcohol, cocaine, methamphetamine, poppers (amyl nitrites), ecstasy—has been associated with HIV transmission and acquisition, among MSM.3,4 Substance use is more prevalent among MSM than among the general population,5–7 and many MSM engage in substance use with sex.6 In the US National HIV Behavioral Surveillance survey, 42% of the MSM reported past year substance use, 74% of whom reported substance use before or during sex.6 Acute effects of substance use can include altered cognition, impaired judgment, and increased sexual desire that are postulated to contribute to risk-taking behaviors among substance-using MSM (SUMSM).3,8,9 These effects are particularly seen with cocaine, poppers, methamphetamine, and binge drinking, each of which have been independently associated with behavioral outcomes that increase HIV risk, including unprotected sex, multiple sex partners, and HIV-serodiscordant partners.3,9–14 Heavy alcohol, methamphetamine, and poppers use have also been attributed to HIV seroconversion in 2 large longitudinal MSM studies.12,13
Many SUMSM use substances recreationally and less than weekly (ie, “episodically”).4,10 However, most research evaluating HIV risk has not distinguished between episodic users and at least weekly users.4,10 In addition, many SUMSM are polysubstance users, defined as using more than 1 substance simultaneously or sequentially during a discrete period of time, yet most research focuses on the relationship between an individual class of substance and HIV risk.10,15–17 To address these gaps in literature, we tested the hypothesis that increasing frequency of substance use and greater number of substances used before or during sex increases the likelihood of engaging in serodiscordant unprotected anal intercourse (SDUAI).
We conducted a cross-sectional survey of HIV-negative SUMSM (age 18 or older) from March 2009 to May 2012 as part of screening for a subsequent mixed-methods study—with qualitative and randomized controlled trial phases—to adapt the Personalized Cognitive Counseling HIV prevention intervention for SUMSM (Project ECHO).18,19 Recruitment was conducted using print advertisements, MSM-specific web sites, and active field recruitment in MSM venues and events. Study protocol was approved by the Committee on Human Research, University of California, San Francisco; Centers for Disease Control and Prevention investigators did not interact with study participants.
SUMSM expressing willingness to be screened for Project ECHO were surveyed by trained staff using a structured telephone questionnaire. Substance use frequency was collected for alcohol, methamphetamine, cocaine (either powdered or crack), and poppers. Situation-level data20 on substance use during or within 2 hours before unprotected anal intercourse (UAI) within the past 6 months were also collected for these substances and for marijuana, ecstasy, heroin, and erectile dysfunctions and nonprescription drugs. In addition, demographic characteristics, sexual behaviors, HIV testing history, and HIV serostatus of sexual partners from the past 6 months were collected.
Our primary outcome was SDUAI, defined as an HIV-negative participant having unprotected anal sex with HIV-positive or unknown status partners.4 Consistent with a previous study, self-reported substance use for cocaine, methamphetamine, and poppers was dichotomized to episodic (less than weekly) use and weekly or more frequent use; self-reported alcohol use was classified as heavy for those who reported drinking 4 or more drinks per day, and moderate for those who reported drinking less than 4 drinks.4 Polysubstance use before or during UAI was calculated as the total number of the following substances taken before or during UAI: methamphetamine, cocaine, alcohol, poppers, crack, ecstasy, and heroin, categorized as using 0, 1, 2, or 3 or more. We conducted sensitivity analyses for polysubstance use including marijuana and erectile dysfunction drug use before or during UAI.
We used multivariable logistic models adjusting for age and race/ethnicity to examine the relationship between SDUAI and the frequency of cocaine, methamphetamine, poppers, and alcohol use and between SDUAI and the categories of polysubstance use. After fitting each model, we contrasted adjacent nonreference categories. We also conducted tests for log-linear trend across the ordered categories, and for departure from log-linear trend, using orthogonal contrasts, under the assumption that the categories are evenly spaced. We note that for the 3-category frequency variables, the test for trend is equivalent to the contrast between the first and third categories, whereas the test for departure assesses evidence for a quadratic pattern across all 3. Adjusted odds ratios (AOR) and Bonferroni-adjusted 95% confidence interval (CI) are reported.
As shown in Table 1, the mean age of the 3173 SUMSM sampled was 33.8 years (SD = 10.5), and the sample was racially and ethnically diverse (51% white, 22% Latino/Hispanic, 10% black, 10% Asian and Pacific Islander, and 7% other/mixed race). Most participants (66%) were recruited in sites within the Castro neighborhood, which has the greatest concentration of MSM venues in San Francisco. Fifteen percent were recruited in sites outside of the Castro and 19% through passive recruitment materials.
HIV Testing and Sexual Behaviors
The majority of SUMSM (67%) reported HIV testing within the previous 6 months. Nearly all (98%) reported oral sex with male partners, 45% reported UAI at least once, 24% reported SDUAI, and 10% reported vaginal sex with women in the last 6 months.
Frequency and Patterns of Substance Use
Episodic substance use was more prevalent than at least weekly use for methamphetamine (12% vs. 6%), cocaine (27% vs. 5%), and poppers (27% vs. 8%). Heavy alcohol consumption was reported by 10%, whereas moderate consumption was reported by 84%. Any substance use before or during UAI was reported by 39%; 11% used 2 classes of substances before or during UAI, and 8% used ≥3 classes. The most common substances used before or during UAI were alcohol (28%), marijuana (18%), poppers (15%), erectile dysfunction drugs (8%), cocaine (8%), and methamphetamine (8%). Five percent reported current substance-use treatment.
For methamphetamine and cocaine, the odds of SDUAI increased with frequency of use (Figure 1A). Specifically, for methamphetamine use, both episodic [AOR, 3.31 (Bonferroni-adjusted 95% CI, 2.55 to 4.28)] and weekly [AOR, 5.46 (95% CI, 3.80 to 7.84)] use was higher risk than nonuse, and weekly was higher risk than episodic use [AOR, 1.65 (95% CI, 1.09 to 2.49)]. Similarly, for cocaine, both episodic [AOR, 1.86 (95% CI, 1.51 to 2.29)] and weekly [AOR, 3.13 (95% CI, 2.12 to 4.63)] users had higher odds of SDUAI than nonusers, and weekly use had higher odds than episodic use [AOR, 1.68 (95% CI, 1.12 to 2.54)]. Both tests for trend for methamphetamine and cocaine were highly statistically significant (P < 0.001). The trend was log-linear for cocaine (P = 0.68), but not for methamphetamine use (P < 0.001). The nonlinear pattern for methamphetamine use reflects smaller incremental effects associated with greater frequency (AOR, 1.65 for weekly vs. episodic compared with 3.31 for episodic vs. nonuse).
Although the odds of SDUAI were elevated among popper users, we did not find strong evidence that risk increased with frequency of use. Compared with nonuse, both episodic [AOR, 2.08 (95% CI, 1.68 to 2.56)] and weekly [AOR, 2.54 (95% CI, 1.85 to 3.48)] use had increased odds of SDUAI, but episodic and weekly use were statistically similar [AOR, 1.22 (95% CI, 0.88–1.70)]. Although there was clear evidence for trend (P < 0.001), driven by the difference in SDUAI risk between weekly and nonusers, the pattern was nonlinear (P = 0.009), reflecting the similarity of episodic and weekly use.
Heavy alcohol users had higher odds of SDUAI than moderate users [AOR, 1.90 (95% CI, 1.43 to 2.51)], but not nonusers [AOR, 1.36 (95% CI, 0.87–2.13)]; accordingly, there was no clear evidence for linear trend (P = 0.13). Although the test for departure from trend suggested a U-shaped pattern (P < 0.001), moderate users and nonusers were statistically comparable [AOR, 0.72 (95% CI, 0.49 to 1.05)].
We found increasing odds of SDUAI with the number of substances reported. In particular, compared with those who did not use any substances before or during UAI, the AORs for SDUAI among MSM who used 1, 2, or 3 or more substances before or during UAI were 16.81 (95% CI, 12.25 to 23.08), 27.31 (95% CI, 18.93 to 39.39), and 46.38 (95% CI, 30.65 to 70.19), respectively (Figure 1B). The test for trend and all comparisons between adjacent categories were highly statistically significant (P < 0.001). However, the pattern was nonlinear (P < 0.001), reflecting smaller incremental effects of using more than 1 substance [AOR, 1.62 (95% CI, 1.15 to 2.29) for 2 vs. 1, AOR, 1.70 (95% CI, 1.10 to 2.63) for 3 or more vs. 2] than the effect of using 1 vs. none (AOR, 16.81). Sensitivity analyses that included marijuana and erectile dysfunction drugs resulted in similar increased odds of SDUAI associated with greater number of substances used.
We found evidence that HIV risk among MSM increases with both the frequency of substance use and the numbers of substances used. For methamphetamine and cocaine, weekly users had higher odds of SDUAI than episodic users, who were in turn at higher risk than nonusers. Similarly, the odds of SDUAI increased across categories of the number of substances reported. For poppers, weekly and episodic use were similar, but both carried higher risk than nonuse. Finally, heavy alcohol users were more likely to report SDUAI than the moderate users.
Our results for cocaine, methamphetamine, and possibly poppers are comparable to previous studies observing dose–response associations for substance use and sexual risk among MSM.3,4 Our findings for alcohol use, which in contrast did not suggest dose–response, were also consistent with other studies reporting that moderate alcohol users were at no higher HIV risk than nonusers, whereas observing that heavy drinking is associated with increased HIV risk.14,21,22 Notably, we collected data on the amount of alcohol consumed, whereas data on frequency of use was collected for methamphetamine, cocaine, and poppers. Although consistent with extant literature, the heterogeneity in measures may explain the differences that we found between alcohol and substance use with respect to their impact on HIV risk.
There are several plausible pathways by which alcohol and substance use may affect HIV risk.3,8,22,23 Specifically, these practices have a myriad of biologic and cognitive effects that may increase sexual risk taking. Moreover, using different classes of substances together or in sequence may activate multiple risk pathways, synergistically increase risk behaviors, and thus, explain some of our findings.3,8
This study has limitations. First, the cross-sectional design limits our ability to make causal inferences. Also, self-reported measures for substance use and sexual risk behaviors may be subject to social desirability and/or recall biases. As with other nonrandomized observational studies, we cannot rule out the possibility of unmeasured confounders that may be associated with both substance use and HIV risk. In particular, these screener data did not include information on person-level characteristics, such as sensation seeking or risk-taking personalities, or extensive socio–demographic covariates.24 In addition, we did not collect data on the amount of use for methamphetamine, cocaine, and poppers, limiting our ability to distinguish between binge and light episodic users. Finally, because our sample was limited to SUMSM from San Francisco, our findings may not be generalizable to other settings. For example, our study had higher substance-use rates relative to National HIV Behavioral Surveillance.6 Additional studies are needed to further examine the putative additive effects of substance use based on data that permit event-level analyses and establish a strong temporal link between substance use and episodes of sexual risks.20 Qualitative studies of polysubstance users can help in determining which combinations of substances contribute to the greatest risk. Despite these limitations, given our large and diverse sample, our findings provide compelling evidence of a dose–response relationship between substance use frequency, increasing polysubstance use, and HIV risk.
In summary, we found that many SUMSM engage in SDUAI, and HIV risk was strongly associated with frequency of use and number of substances used before or during unprotected sex. This has several public health implications. SUMSM may benefit from strategies that build self-efficacy and promote skills for explicit HIV-serostatus communication with partners. Given the low rates of current self-help or substance-use treatment utilization among SUMSM in this sample, there is an urgent need to expand interventions beyond treatment settings and target existing evidence based–HIV prevention interventions to episodic users. Efforts similar to Project ECHO are needed to develop and evaluate HIV risk-reduction interventions adapted specifically for nondependent episodic SUMSM. Interventions that target SUMSM should also address a wider spectrum of substance-use patterns and increasing risks associated with polysubstance use.
This research was supported by the Centers for Disease Control and Prevention under cooperative agreement UR6PS000684 to Public Health Foundation Enterprises, City of Industry, CA. The authors acknowledge John Farley, Alic Shook, Reggie Gage, and the study field recruitment team for their invaluable contributions during data collection.
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HIV; MSM; sexual risk behaviors; substance use; alcohol use; methamphetamine; cocaine; poppers
© 2013 by Lippincott Williams & Wilkins
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