Controlling Healthcare-Associated Infections in the International Research Setting

Godfrey, Catherine MD, FRACP*; Villa, Christie BA; Dawson, Liza PhD; Swindells, Susan MBBS; Schouten, Jeffrey T. MD, JD

JAIDS Journal of Acquired Immune Deficiency Syndromes: 1 April 2013 - Volume 62 - Issue 4 - p e115–e118
doi: 10.1097/QAI.0b013e3182845b95
Letters to the Editor

*HIV Research Branch, Therapeutics Research Program, Division of AIDS, National Institutes of Health/National Institute of Allergy and Infectious Diseases, Washington, DC

Vaccine and Infectious Disease Division, Fred Hutchinson Cancer Research Center, Seattle, WA

Research Ethics Team, Basic Sciences Program, Division of AIDS, National Institutes of Health/National Institute of Allergy and Infectious Diseases, Washington, DC

Department of Medicine, University of Nebraska Medical Center, Omaha, NE

Vaccine and Infectious Disease Division, University of Nebraska Medical Center, Omaha, NE

Correspondence to: Catherine Godfrey, MD, FRACP, Division of AIDS, National Institutes of Health/National Institute of Allergy and Infectious Diseases, 6700 B Rockledge Drive, Bethesda, MD 20892 (e-mail:

The Office of HIV/AIDS Network Coordination has been funded in whole or in part with Federal funds from the Division of AIDS (DAIDS), National Institute of Allergy and Infectious Diseases, National Institutes of Health, Department of Health and Human Services, Grant 5 U01 AI068614, entitled Leadership Group for a Global HIV Vaccine Clinical Trials (Office of HIV/AIDS Network Coordination). The project described was supported by Award Number U01AI068636 from the National Institute of Allergy and Infectious Diseases and supported by National Institute of Mental Health (NIMH), National Institute of Dental and Craniofacial Research (NIDCR). The content is solely the responsibility of the authors and does not necessarily represent the official views of the National Institute of Allergy and Infectious Diseases or the National Institutes of Health.

The authors have no conflicts of interest to disclose.

Article Outline

To the Editors:

Standard infection control precautions and centralized prevention/education has improved health care outcomes for patients and health care workers (HCWs).1–3 In resource-limited health care settings, implementation of these practices is challenging and transmission of highly resistant organisms within health care facilities is described.4–7 High rates of needle stick injuries8 and unsafe injection practices9 occur in clinics and hospitals where blood borne infections such as hepatitis and HIV are common; postexposure prophylaxis is infrequently accessed.10 Alcohol gels are perceived as expensive and may be unavailable, and many settings lack appropriate hand-washing facilities.11 Personal protective equipment is often absent, and medical equipment may be old and in disrepair. Strict standards for environmental controls are difficult to maintain, and health care facilities themselves are often archaic. International recommendations are available for infection control, but programs are not consistently regulated and have few monitoring and enforcement programs.12–14

The National Institute of Allergy and Infectious Diseases (NIAIDs) supports 6 networks conducting HIV-related clinical research. Many clinical research sites (CRSs) are located outside of the United States in resource-limited settings. CRS that have access to the patients and resources necessary to perform high-quality research are limited and usually engage in diverse research. A single site might have studies focusing on the prevention of mother-to-child transmission of HIV, intensive pK studies involving new drugs for multiresistant organisms, and protocols testing second-line antiretroviral therapy. Standard clinical care is provided in often-crowded facilities, where research subjects are present for many hours. Anecdotal observations have suggested that there are significant variations in infection control practices among the sites.

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A survey of the infection control resources and practices at the CRS outside of the United States was undertaken, led by the Office of HIV/AIDS Network Coordination. Sites were asked about a formal infection control program, staff safety, respiratory hygiene and tuberculosis control, hand hygiene capabilities, injection practices, and blood safety.

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Overall, 74 sites were offered the survey, and 32 returned completed surveys. Twenty-three of 32 AIDS Clinical Trials Group sites completed the survey. Selected results are summarized in Figure 1.

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Infection Control Organization

Eighty-six percent of sites had an infection control policy, of these 55% were specific to the CRS. Seventy-five percent of sites had an infection control officer, directly employed by the sites, half the time. The sites without an infection control policy frequently did not have policies addressing the domains surveyed.

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Sixty percent of sites reported a triage system to identify participants with potential respiratory infections. Commonly, the study participant was placed in a well-ventilated area and provided a mask. Less than half of respondents (45.2%) conduct protocol procedures with participants with known or suspected tuberculosis (TB) in a separate clinical area. Natural and mechanical ventilation were common methods of ensuring respiratory hygiene. N95 masks were available in the general clinic, in 39% of sites (12/31). Ultraviolet lights were present in 8/29 general clinical areas and 4/13 dedicated sputum collection areas indoors. A dedicated space for sputum collection was present in 55% of the CRSs. Space for sputum collection was most commonly an area outside (approximately 55%) or a dedicated sputum collection area inside (approximately 45%). In the space for sputum collection, natural and mechanical ventilation were used as infection control measures. Twenty-five percent of sites reported surgical masks worn by patients. Staffs were provided N95 masks 50% of the time in the dedicated sputum collection area; 2/11 sites reported that N95 respirators were available. Educational material on cough hygiene was available at 40% of the respondent sites. Forty-five percent of sites had TB surveillance programs for staff and routinely screened staff for TB infection 71% of the time.

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Hand Hygiene

All sites reported sinks with running water; most had manual soap dispensers (25/32) and paper hand towels (27/32). Hand sanitizers were available at half of the sites. Water basins filled remotely were used in some areas in 15/32 sites, bar soap in 13/32 sites, and cloth hand towels in 11/32 sites.

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Blood Safety

All sites reported a policy for management of needle stick injuries, and all sites had appropriate postexposure prophylaxis for HIV. The source patient is tested for hepatitis B at 58% of sites and hepatitis C at 39% of sites. Postexposure protocols for hepatitis B were present in 42% of sites. Most sites reported a needle recapping policy (71%), and 58% used safe needle systems. Sharps containers were generally available.

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Healthcare-associated infections are an important cause of morbidity for patients, and health care providers in resource limited settings. A recent meta-analysis suggested that rates of indicator healthcare-associated infections might be more than double those of resource rich settings.15 Our survey suggested important areas for improvement in the delivery of health care associated with NIAID-sponsored clinical trials.

There is good evidence that organizational support for infection control reduces the transmission of infectious agents and reduces mortality and morbidity in the acute care setting.16,17 Critical elements include staff trained in the principles of infection prevention, surveillance, and enforcement of preventative measures. Prevention of occupational illnesses requires preemployment assessments and immunization for vaccine-preventable illnesses. A quarter of the sites did not have appropriate personnel tasked with infection prevention. Those sites that did not have specific policies related to infection control also did not have policies to address most of the infection control domains.

TB transmission in the health care environment is well described. The association with HIV infection is important, and instances of transmission clusters of highly resistant TB have been documented.18,19 A review examining the incidence and prevalence of latent TB infection among HCW in low- and middle-income countries suggested that HCW were at significant risk for TB disease compared with the general population.20 Even in areas where transmission of TB has been described, infection control procedures may be lacking. In eThekwini Municipality, Durban, RSA, only a quarter of primary health clinics triaged patients with cough. This is consistent with our experience. Patients with known or suspected TB are seen in the same facility as patients without TB, and segregation of individuals who might be infectious is not commonly undertaken. Cough hygiene has been promoted in resource-rich settings as a way of reducing spread of respiratory pathogens, fewer than half the sites had information available about cough hygiene.

Hand hygiene is a critical measure to reduce health-care-acquired infections. Improvement of hand hygiene practices has been associated with reduced infection rates in hospitalized patients.21 In 2009, the WHO described best practices for hand hygiene and methodologies for local manufacture of inexpensive hand sanitizing gel.22,23 The multimodal strategy was tested in a reference hospital in Mali and found to be feasible, affordable, and effective.24 The WHO has ongoing efforts to promote hand hygiene using alcohol-based hand rubs throughout the world; however, a recent survey in Uganda of attitudes toward infection control gel for hand hygiene was perceived to be expensive and unavailable.11 In our survey, hand hygiene practices varied widely; alcohol-based gel was not generally available. The use of hand basins with standing water accompanied by bar soap and multiuse towels was striking.

HCW are at risk for infection with blood borne pathogens, and needle stick injuries are common. One survey in Malawi suggested that half of nurses had a needle stick injury within the previous year.25 This rate is similar to rates in resource-rich settings before the widespread adoption of engineered needle-safe solutions.26 The consequences of outdated needle practices combined with high prevalence rates of HIV, hepatitis B, and hepatitis C may be catastrophic.27 Although postexposure prophylaxis is available for injuries that might be capable of transmitting HIV, it is unknown to what extent the work force is at risk for hepatitis B, as the information is not collected before employment.

Participation in research should not place patients at more risk when compared with the local standard of care. The concentration of patients with communicable diseases drawn to the research site to participate in clinical protocols and the need for prolonged face-to-face interactions could lead to an increased risk for preventable infections in the research setting compared with the clinical environment. Arguably, research settings should set and demonstrate higher standards for clinical care, even when these levels cannot be implemented immediately throughout the health care system. Ethicists have commented that researchers should not replicate unacceptably low local standards but should seek to establish competent levels of care that can ultimately be feasibly implemented in the health system, for the benefit of all patients.28,29

Our survey demonstrated important areas for improvement in infection prevention. There are good precedents in the resource-limited setting for developing standards for hand hygiene and the prevention of blood borne illnesses. The most pressing need is for a protocol for the prevention of TB transmission. This has been developed and is being implemented at our sites. TB infection control, however, is best undertaken in an environment of other infection prevention efforts. NIAID and other research sponsors have a unique opportunity to model better health care infection control practices; it is hoped that this will lead to improved health care outcomes.

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1. Haley RW, Culver DH, White JW, et al.. The efficacy of infection surveillance and control programs in preventing nosocomial infections in US hospitals. Am J Epidemiol. 1985;121:182–205.
2. Harries AD, Zachariah R, Tayler-Smith K, et al.. Keeping health facilities safe: one way of strengthening the interaction between disease-specific programmes and health systems. Trop Med Int Health. 2010;15:1407–1412.
3. Burke JP. Infection control - a problem for patient safety. N Engl J Med. 2003;348:651–656.
4. Naidoo S, Seevnarain K, Nordstrom DL. Tuberculosis infection control in primary health clinics in eThekwini, KwaZulu-Natal, South Africa. Int J Tuberc Lung Dis. 2012;16:1600–1604.
5. Kanjee Z, Amico KR, Li F, et al.. Tuberculosis infection control in a high drug-resistance setting in rural South Africa: information, motivation, and behavioral skills. J Infect Public Health. 2012;5:67–81.
6. Andrews JR, Gandhi NR, Moodley P, et al.. Exogenous reinfection as a cause of multidrug-resistant and extensively drug-resistant tuberculosis in rural South Africa. J Infect Dis. 2008;198:1582–1589.
7. O'Donnell MR, Jarand J, Loveday M, et al.. High incidence of hospital admissions with multidrug-resistant and extensively drug-resistant tuberculosis among South African health care workers. Ann Intern Med. 2010;153:516–522.
8. Omorogbe VE, Omuemu VO, Isara AR. Injection safety practices among nursing staff of mission hospitals in Benin City, Nigeria. Ann Afr Med. 2012;11:36–41.
9. Phillips EK, Simwale OJ, Chung MJ, et al.. Risk of blood borne pathogen exposure among Zambian healthcare workers. J Infect Public Health. 2012;5:244–249.
10. Esin IA, Alabi S, Ojo E, et al.. Knowledge of human immunodeficiency virus post-exposure prophylaxis among doctors in a Nigerian tertiary hospital. Niger J Clin Pract. 2011;14:464–466.
11. Sethi AK, Acher CW, Kirenga B, et al.. Infection control knowledge, attitudes, and practices among healthcare workers at Mulago Hospital, Kampala, Uganda. Infect Control Hosp Epidemiol. 2012;33:917–923.
12. WHO. WHO policy on TB infection control in health-care facilities, congregate settings and households. 2009. Available at: Accessed November 8, 2012.
13. Siegel JD, Rhinehart E, Jackson M, et al., Health Care Infection Control Practices Advisory C. 2007 guideline for isolation precautions: preventing transmission of infectious agents in health care settings. Am J Infect Control. 2007;35(10 suppl 2):S65–S164.
14. WHO. Core components for infection prevention and control programmes. 2008. Available at: Accessed November 8, 2012.
15. Allegranzi B, Bagheri Nejad S, Combescure C, et al.. Burden of endemic health-care-associated infection in developing countries: systematic review and meta-analysis. Lancet. 2011;377:228–241.
16. Sydnor ER, Perl TM. Hospital epidemiology and infection control in acute-care settings. Clin Microbiol Rev. 2011;24:141–173.
17. Finch R. Current challenges in antimicrobial resistance and healthcare-associated infections: role and organization of ARHAI. J Antimicrob Chemother. 2012;67(suppl 1):i3–i10.
18. Wines M. Virulent TB in South Africa May Imperil Millions. Available at: Accessed November 2, 2012.
19. Gandhi NR, Moll A, Sturm AW, et al.. Extensively drug-resistant tuberculosis as a cause of death in patients co-infected with tuberculosis and HIV in a rural area of South Africa. Lancet. 2006;368:1575–1580.
20. Joshi R, Reingold AL, Menzies D, et al.. Tuberculosis among health-care workers in low- and middle-income countries: a systematic review. PLoS Med. 2006;3:e494.
21. Pittet D, Allegranzi B, Sax H, et al.. Evidence-based model for hand transmission during patient care and the role of improved practices. Lancet Infect Dis. 2006;6:641–652.
22. WHO. WHO Guidelines on Hand Hygiene in Health Care. 2009. Available at: Accessed November 2, 2012.
23. WHO. Guide to Local Production: WHO-Recommended Handrub Formulations. 2010. Available at: Accessed November 2, 2012.
24. Allegranzi B, Sax H, Bengaly L, et al.. Successful implementation of the World Health Organization hand hygiene improvement strategy in a referral hospital in Mali, Africa. Infect Control Hosp Epidemiol. 2010;31:133–141.
25. van Oosterhout JJ, Nyirenda M, Beadsworth MB, et al.. Challenges in HIV post-exposure prophylaxis for occupational injuries in a large teaching hospital in Malawi. Trop Doct. 2007;37:4–6.
26. Tuma S, Sepkowitz KA. Efficacy of safety-engineered device implementation in the prevention of percutaneous injuries: a review of published studies. Clin Infect Dis. 2006;42:1159–1170.
27. Prüss-Ustün A, Rapiti E, Hutin Y. Global burden of disease from sharps injuries to health-care workers. 2003. Available at: Accessed November 2, 2012.
28. London AJ. The ambiguity and the exigency: clarifying ‘standard of care’ arguments in international research. J Med Philos. 2000;25:379–397.
29. Hyder AA, Dawson L. Defining standard of care in the developing world: the intersection of international research ethics and health systems analysis. Dev World Bioeth. 2005;5:142–152.
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