Enter your Email address:
Wolters Kluwer Health may email you for journal alerts and information, but is committed
to maintaining your privacy and will not share your personal information without
Cairo, Cristiana; Urban, Elizabeth; Li, Haishan; Poonia, Bhawna; Armstrong, Cheryl L; Riedel, David; Redfield, Robert; Pauza, C David
Institute of Human Virology, University of Maryland School of Medicine
Acute HIV infection is characterized by uncontrolled viremia and rapid depletion of CD4+ and CD4- cell subsets. Cell depletion is a cascade of direct virus cytopathicity, immune activation and FasL-dependent cell death that remodels the immune system and allows the establishment of persistent infection. Among the cell subsets that are impacted during acute infection are the γδ T and NK cells. These subsets have overlapping functions for secreting Type 1 cytokines (TNFα and IFNγ), direct cytolysis of infected cells and indirect cell killing through antibody-dependent cellular cytotoxicity (ADCC). Effector cells from both subsets are characterized by expression of CD56 and NKG2D. The acute loss of CD56+ γδ T and NK cells may be linked through cell regulatory networks controlled by costimulatory molecules including 4-1BB, and it is possible that a single event leads to changes in both lymphocyte populations. We also noted a strong correlation between HIV acquisition and high activity alleles of the FCGR3A genes (Fc receptor γIIIa), suggesting that natural antibody may have a role in signaling these innate immune cells and triggering the events of cell depletion. The loss of potent ADCC effector subsets during acute HIV disease, will prevent nascent, HIV-specific antibodies from attacking infected cells and slowing virus spread. Decreased levels of pro-inflammatory cytokines TNFα and IFNγ, will lower the effectiveness of cellular immunity. The impact of HIV infection to debilitate innate immune responses and blunt the effectiveness of virus-specific acquired immunity, reveals a complex mechanism for immune evasion and the establishment of persistent infection. Persons with natural control of viremia do not have γδ T or NK cell defects and this difference accounts in part, for their ability to avoid progressing disease.
© 2011 Lippincott Williams & Wilkins, Inc.
Colleague's E-mail is Invalid
Your Name: (optional)
Separate multiple e-mails with a (;).
Thought you might appreciate this item(s) I saw at JAIDS Journal of Acquired Immune Deficiency Syndromes.
Send a copy to your email
Your message has been successfully sent to your colleague.
Some error has occurred while processing your request. Please try after some time.
An Existing Folder
A New Folder
The item(s) has been successfully added to "".
Login with your LWW Journals username and password.
Username or Email:
Enter and submit the email address you registered with. An email with instructions to reset your password will be sent to that address.
Link to reset your password has been sent to specified email address.
What does "Remember me" mean?
By checking this box, you'll stay logged in until you logout. You'll get easier access to your articles, collections,
media, and all your other content, even if you close your browser or shut down your
To protect your most sensitive data and activities (like changing your password),
we'll ask you to re-enter your password when you access these services.
What if I'm on a computer that I share with others?
If you're using a public computer or you share this computer with others, we recommend
that you uncheck the "Remember me" box.
Save my selection
Article Level Metrics