118 Inhibiting CCR5 in vitro and in vivo
JAIDS Journal of Acquired Immune Deficiency Syndromes:
I will describe collaborative research on CCR5 small molecule inhibitors of HIV-1 entry. In particular I will discuss how HIV-1 develops resistance to this drug class in vitro. I will also show how these compounds can be used to prevent HIV-1 transmission in the macaque model when applied as a vaginal microbicide, both as a gel and as a vaginal ring. I will also address how such approaches can be combined with vaccination to make a more effective prevention science strategy.© 2011 Lippincott Williams & Wilkins, Inc.