Enter your Email address:
Wolters Kluwer Health may email you for journal alerts and information, but is committed
to maintaining your privacy and will not share your personal information without
You currently have no recent searches
Blattner, William A M.D.
Institute of Human Virology, School of Medicine, University of Maryland, Baltimore, MD
HIV has been linked to malignancy since the first reports of Kaposi Sarcoma were a harbinger of the pandemic to come. Two herpes viruses, EBV (certain lymphomas) and HHV-8 (KSHV) (Kaposi Sarcoma) and pathogenic strains of HPV (cervical cancer) have been linked to the majority of AIDS-defining malignancies. These viruses are also linked to a number of cancers elevated in patients with HIV including some lymphomas (EBV and HHV8), Primary Effusion lymphoma (HHV-8), hepatocellular cancers (HBV, HCV) and penile and anal cancers (HPV). Through AIDS cancer matching studies and HIV cohort and clinical analyses a broader spectrum of HIV-associated malignancies have been reported and in European and US cohorts cancer is the leading cause of death in the HAART era as patients survive longer. Some such as Hodgkins disease are EBV associate while other such as lung cancer have yet to have an etiologic association with viruses. In sub-Saharan Africa, information on HIV-associated malignancies is sparse and with the exception of an AIDS Cancer Match study from Uganda are descriptive. With the scale up of antiretroviral therapy, the PEPFAR program provides an important platform for expansion of cancer research since it represents the largest cohort of HIV infected patients ever assembled. There are significant opportunities to define the spectrum of HIV-associated malignancies through improved integration of HIV and oncology services. Additionally, studies of these malignancies may provide new insights concerning viral etiology of cancer in HIV-infected cohorts. For example in West Africa, new strains of HTLV, HTLV-3 and HTLV-4 have been described that have yet to be linked to human disease, and emerging data link HPV to certain forms of head and neck cancer. Linking epidemiological cohorts to cancer virology basic study provides a path for expanding insights about the role of viruses in malignancy.
© 2011 Lippincott Williams & Wilkins, Inc.
Colleague's E-mail is Invalid
Your Name: (optional)
Separate multiple e-mails with a (;).
Thought you might appreciate this item(s) I saw at JAIDS Journal of Acquired Immune Deficiency Syndromes.
Send a copy to your email
Your message has been successfully sent to your colleague.
Some error has occurred while processing your request. Please try after some time.
An Existing Folder
A New Folder
The item(s) has been successfully added to "".
Login with your LWW Journals username and password.
Username or Email:
Enter and submit the email address you registered with. An email with instructions to reset your password will be sent to that address.
Link to reset your password has been sent to specified email address.
What does "Remember me" mean?
By checking this box, you'll stay logged in for
days or until you logout. You'll get easier access to your articles, collections,
media, and all your other content, even if you close your browser or shut down your
To protect your most sensitive data and activities (like changing your password),
we'll ask you to re-enter your password when you access these services.
What if I'm on a computer that I share with others?
If you're using a public computer or you share this computer with others, we recommend
that you uncheck the "Remember me" box.
Save my selection