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JAIDS Journal of Acquired Immune Deficiency Syndromes:
doi: 10.1097/QAI.0b013e3181acff91
Epidemiology and Social Science

Using Social Networks to Recruit an HIV Vaccine Preparedness Cohort

Valente, Thomas W PhD*; Zogg, Jennifer B PhD*†; Christensen, Shawna MS*; Richardson, Jean DrPH*; Kovacs, Andrea MD†; Operskalski, Eva PhD†

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Author Information

From the Departments of *Preventive Medicine; and †Pediatrics, Keck School of Medicine, University of Southern California, Los Angeles, CA.

Received for publication December 4, 2008; accepted May 5, 2009.

Parts of these data were presented at Sunbelt XXV, International Sunbelt Social Network Conference, International Network for Social Network Analysis, February 19, 2005, Redondo Beach, CA, and International HIV Vaccine Conference, September 2005, Montreal, Quebec, Canada.

Overall support for the Pediatric AIDS Clinical Trials Group (PACTG), now the International Maternal Pediatric Adolescent AIDS Clinical Trials Group (IMPAACT), was provided by the National Institute of Allergy and Infectious Diseases (U01 AI068632) and by the Eunice Kennedy Shriver National Institute of Child Health and Human Development. The content is solely the responsibility of the authors and does not necessarily represent the official views of the National Institute of Allergy and Infectious Diseases or the National Institutes of Health. This work was supported by the Contract PACTG.31.FM.01, Collaborative Approach to HIV Vaccine Preparedness, Social and Scientific Systems, Inc, under Cooperative Agreement No. U02 AI41089, National Institute of Allergy and Infectious Diseases.

Correspondence to: Thomas W. Valente, PhD, 1000 S Fremont Avenue, Bldg A-5133, Alhambra, CA 91803 (e-mail: tvalente@usc.edu).

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Abstract

Objectives: To evaluate a social network approach to develop an adolescent cohort for HIV vaccine preparedness and investigate characteristics that influence recruitment.

Methods: We summarize baseline data from a prospective cohort study that included 4 sessions over 6 months. Fifty-nine HIV-infected adolescent and adult patients of a family-based HIV clinic named significant others and indicated willingness to involve them in this study. Sixty-two adolescent and adult significant others not known to be HIV infected were enrolled. Logistic regression was used to estimate factors associated with willingness.

Results: Participants identified 624 social network members including 276 adolescents (44%). Network member's awareness of the index's HIV positivity (P < 0.01) and older age (P = 0.05) affected willingness. Respondents were less willing to invite drug-risk alters (P = 0.006). Adolescents were willing to invite more adolescents than were adults (P < 0.0001). Adolescents younger than 18 years old reported fewer sexual and drug-using risk behaviors than expected.

Conclusions: HIV-infected patients are willing to recruit their social networks, provided concerns about disclosure of HIV status are addressed. Using social networks to identify and recruit adolescent populations is appropriate and feasible for vaccine preparedness activities, future vaccine trials, and other prevention programs, but procedures are needed to selectively identify and retain high-risk youth.

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INTRODUCTION

As scientists debate the challenges presented by HIV vaccine research, basic vaccine discovery work continues. When a product becomes available, its efficacy will be evaluated among large samples of those most at risk for acquiring HIV. Vaccine preparedness studies and HIV vaccine trials conducted in the United States have shown that high-risk populations of adult men and women can be successfully recruited, enrolled, and retained using targeted recruitment strategies.1-3

Although high-risk adolescents may be successfully recruited into HIV prevention research,4,5 it is not known whether this is true for HIV vaccine studies in the United States. Early initiation of sexual behavior, multiple sexual partners, and high rates of sexually transmitted infections (STIs) increase the risk of HIV among youth relative to other age groups.6 Indeed, people younger than the age of 25 years account for over 50% of all new HIV infections in the United States.7 The development of an HIV vaccine that could be given before a young person becomes sexually active may be essential to reducing the number of new infections among youth, and this vaccine will need to be tested in this age group.

Yet, youth most at risk for HIV are often difficult to reach with interventions and research protocols. They tend to come from communities of color, immigrants, and the poor, among whom substantial mistrust of research can be an important barrier.8 The very factors that put youth at risk (eg, sexual behavior and reduced access to health care and education) make them vulnerable to problems resulting from participation in clinical efficacy trials, including stigmatization, discrimination, and problems in interpersonal relationships.1,9,10 Young people, for instance, are more likely than older adults to report negative reactions from friends, family members, or coworkers, who may assume that trial participation signals HIV infection.9 Adolescents may be particularly impacted by negative reactions because peer norms and values figure prominently in adolescent concerns and decision making.11 To avoid these social harms, processes must be established that will address misconceptions among youth and their families about vaccine trials and prevent inadvertent disclosure of trial participation.1,4,12-14 Investigators must also develop effective HIV education and prevention strategies to minimize increases in risky sexual and drug using behaviors that may result from a mistaken assumption of being protected by the vaccine.10

This study was designed to evaluate the potential effectiveness of a social network approach to develop a cohort of adolescents for HIV vaccine preparedness activities and determine participants' willingness to participate in future HIV vaccine trials. The main insight of social network analysis is its focus on the connectivity or link between an individual and significant others.15,16-20 Because adolescents often derive their understanding of appropriate norms and behaviors from their peers, these links represent a primary locus of behavioral influence that may provide a vehicle by which at-risk youth can be identified and recruited.

Recruitment of high-risk individuals for HIV vaccine preparedness studies has often used a venue approach in which researchers identify recruitment locales and invite patrons to participate.2,21-24 This method is limited because the prevalence of risk behavior is variable and chosen settings might lack a sufficient number of eligible recruits. Also, singling out particular groups by high-risk locales (eg, gay bars) might invite the resistance of business owners and patrons, hindering recruitment in those areas and further stigmatizing the vaccine. Another approach is to embed recruitment within community- or clinic-based services, such as syringe exchange or drug treatment programs.25 However, individuals at highest risk may not seek such services, which in any case may be limited in some communities. Moreover, people approached in this way might actually be less likely to participate than those reached by newspaper advertisements or other study participants.2 Researchers also commonly employ mass media or other communication outreach. This technique may reach many potential participants but is not sufficiently selective and may identify people who do not qualify as high risk.2,21,24

Social network approaches to recruitment have been used in several prevention studies26-29 but not, to our knowledge, for clinical trials. In addition to evaluating the effectiveness of the approach in this context, we investigated sociodemographic and network characteristics that might influence recruitment in such studies, as well as the effects of knowledge about HIV and HIV vaccines. Results have implications for recruitment into any clinical trial testing HIV-preventive biological agents.

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MATERIALS AND METHODS

Study Design and Population

This article reports baseline results from a prospective cohort study. Participation involved 4 visits (baseline, 2 weeks, and 3 and 6 months) and 2 interim telephone calls to update locator information. The design enabled evaluation over time of factors relevant to participation and retention in a hypothetical vaccine trial. From October 2004 through March 2006, HIV-infected adolescent (12-24 years) and adult female (>24 years) patients from the Los Angeles County + University of Southern California Maternal Child and Adolescent Center for Infectious Diseases and Virology (MCA) were recruited from a random-ordered list of current patients by telephone or at their clinic visit. We originally enrolled only adolescents but in December 2005 began enrolling female adult patients because anecdotal evidence from study interviews suggested that many of these women would be willing to recruit their HIV-uninfected adolescent children and relatives. Enrolled patients were designated indexes. The study protocol was approved by the local institutional review board. Informed consent was obtained from all participants and, if minors, assent was obtained and consent obtained from their parent or legal guardian.

MCA is a comprehensive multidisciplinary center of care that has served over 3000 HIV-infected women, children, adolescents, and their families since 1988. It currently serves 400 families that include 894 patients, of whom 153 (57% HIV infected) are adolescents and 385 (99% HIV infected) are adults. Seventy percent are Latino, 25% Black, and 5% from other groups.

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Identification and Recruitment of Network Members (Alters)

To identify the indexes' social network members (first-degree alters), we asked indexes during the baseline interview to name up to 5 individuals in each of 5 groups: (1) family members, (2) closest friends, (3) sexual partners in the past 6 months (sexual-risk alters), (4) people with whom they used alcohol, marijuana, or drugs in the past 6 months (drug-risk alters), and (5) others with whom they spend time. For each alter named, the index provided information about their specific relationship (eg, neighbor, school, or work friend), alter's age, whether the alter knew that the index was HIV infected, and whether the index was willing to invite the alter to participate in this study. Indexes were then asked to bring their alters to the clinic to participate in the study and were given a $5.00 “finder's fee” for each alter they recruited. Enrolled first-degree alters were asked to provide the same information about their social network members (second-degree alters), although we did not enroll them into this pilot study. Alter enrollment continued through June 2006.

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Study Visits

The baseline interview included questions about sociodemographic characteristics, health history, alcohol and drug use, sexual behavior, knowledge about HIV, and, for alters only, attitudes about people with HIV. After participants read an HIV vaccine fact sheet, we assessed their knowledge about HIV vaccines, willingness to invite family, friends, and risk partners to participate in future HIV vaccine trials, and for alters only, willingness, motivations/barriers to participating in such trials.

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Data Collection Instruments

Questions about sociodemographic characteristics, health history, alcohol and drug use, and sexual behavior were adapted from the HIV Network for Prevention Trial Vaccine Preparedness Study,1 as were assessments of baseline HIV vaccine knowledge (4 true/false questions), willingness to participate or ask alters to participate in future HIV vaccine trials (four 4-level Likert questions), and motivations and barriers to participating in future HIV vaccine trials (twenty-three 4-level Likert items). Assessments of HIV knowledge (nineteen 5-level true/false scale questions) and attitudes about people with HIV (nine 3-level Likert items) were modified from the CDC Handbook for Evaluating HIV Education.30 The 2-week HIV vaccine reassessment consisted of 17 true/false items modified from the Adolescent Trials Network comprehension test.31

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Statistical Analyses

Analyses were based on data from the baseline interview. We first compared sociodemographics, risk behaviors, HIV and HIV vaccine knowledge, and network characteristics of indexes and enrolled first-degree alters stratified by adolescent or adult age group. Next, we compared age and network type (risk relationship) between first- and second-degree alters to investigate whether the second wave of alters would yield a sufficiently high-risk sample of youth. P values were estimated from χ2 tests for categorical variables and independent t tests for mean comparisons or Wilcoxon rank sum tests for median comparisons.

The next series of analyses were designed to evaluate characteristics of respondents and each of their alters (as reported by the respondent) that impacted the respondent's willingness to invite the alter to participate in the study. We reshaped the data to be dyadic such that each observation was either an index and first-degree alter pair or enrolled first-degree and second-degree alter pair.15,32 The dyadic data are nonindependent and clustered on the respondent, and appropriate multilevel models were specified.33 All variables with P < 0.10 in univariate analyses were considered for inclusion, and only variables with P < 0.10 remained in the final multivariate model. Odds ratios, 95% confidence intervals, and P values were estimated from logistic regression with generalized estimating equations.

To investigate whether adolescents or adults were more willing to invite adolescents into this study, we used a logistic regression model to estimate the difference between adolescents and adults. We used independent t tests to compare adolescent and adult participants with respect to total number of adolescents they named and number they were willing to invite.

We used Spearman correlation coefficients to investigate whether willingness to invite named family, friends, and risk partners into this vaccine preparedness study was associated with level of willingness to invite them into a future HIV vaccine study.

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RESULTS

Cohort Characteristics

Table 1 summarizes key characteristics of the 59 indexes and 62 first-degree alters enrolled in the study (adolescents vs. adults). Indexes were MCA patients for a median of 5.6 years. Adolescent indexes were less likely than adults to be infected hetero- or homosexually; 61% were infected perinatally or by transfusion. Although most of the adolescent and adult indexes were female, the sex distribution among alters was balanced. Age, race and ethnicity, education, and birth in the United States were similar for indexes and alters in both age groups. Both adolescent and adult indexes were more likely than alters to have participated in a health research study due to MCA's active clinical research program. Although some adolescent indexes were homosexual, all adolescent alters were heterosexual. Most indexes and alters <18 years old had not had vaginal or anal sex. Among participants who reported ever having sex, >75% in all groups reported ≤1 sexual partner in the previous 3 months. Condom use was more consistent among adolescent indexes than adolescent alters. In adults, indexes were more likely to have had an STI than alters. Among those who responded, approximately 50% of adolescents had used alcohol, tobacco, or marijuana, whereas >70% of adults had. Less than 25% of all groups had used other drugs, and injection drug use was rare. Whereas adolescent indexes and alters had a comparable level of knowledge about HIV, adult indexes had greater knowledge than did adult alters. Adult alters had more positive attitudes about people with HIV than did adolescent alters. On average, indexes and alters named 4-6 social network members and were willing to invite ≥60% of them into this study.

Table 1
Table 1
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Table 1
Table 1
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Social Network Characteristics

Figure 1 depicts the process of identifying social network members. The 59 indexes identified 337 individual first-degree alters. Of these, 306 were named during the study interview and 31 (10%) were enrolled. Two indexes refused to name any alters and 1 index named 13 (median = 4). Indexes also recruited 31 alters not named during the interview. These 62 enrolled alters named 357 second-degree alters (range = 0-15, median = 5), and of these 339 individuals, 287 had not been previously named by either indexes or first-degree alters. In sum, the 59 indexes yielded 624 nonduplicated social network members who could potentially be enrolled in an HIV vaccine preparedness effort.

Figure 1
Figure 1
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Figure 2 shows examples of the size, nature, and variety of the social networks observed in this study, as well as whether the network member was willing to participate in vaccine preparedness activities. The median network size was 8 (range = 1-52) and respondents were willing to invite a median of 5 (range = 0-31) network members. Indexes and alters sometimes identified the same alters (Fig. 2A). Some participants reported willingness to invite all the alters they named (Fig. 2B, left side), but others were willing to invite only a select few (Fig. 2B, right side). The networks have varying degrees of overlap among their members. Some indexes recruited alters who also named the index and the same alters (Fig. 2C); others named alters who did not name each other and these alters exhibited varied patterns of willingness (Fig. 2D). In (Fig. 2D), the index named many alters who also named many alters, generating a comparatively large pool of potential participants.

Figure 2
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The comparison of the characteristics of first- and second-degree alters (Table 2) showed that approximately 50% of both groups were children or adolescents. Second-degree alters were marginally less likely to be family members and more likely to be drug-risk partners.

Table 2
Table 2
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Willingness to Invite Alters to Participate in Vaccine Preparedness Activities

Indexes and alters reported willingness to invite 421 (66%) of 635 social network members they named (data are missing for 29 alters). Univariate analyses (Table 3) showed that indexes and alters were similarly willing to invite alters. Adolescents were less willing than adults. HIV knowledge was positively associated with willingness, but knowledge about HIV vaccines and attitudes about people with HIV were not. There was a borderline positive association with history of an STI. Respondents were less willing to invite children or adolescents than adults and sexual- or drug-risk partners than family members. Indexes were more willing to invite alters who knew their HIV-positive status than alters who did not know their status. They were also more willing than were HIV-uninfected respondents to invite their alters. In multivariate analysis, the relationships between willingness and network member's older age, awareness of an index's HIV positivity, and drug risk remained significant. Despite a strong association in the univariate analysis, HIV knowledge was only marginally associated with willingness after adjusting for other factors.

Table 3
Table 3
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Table 3
Table 3
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Additional analyses showed that although adults were more willing to invite the adolescents they named (90% vs. 60%, P = 0.002), on average, adolescents named more adolescents (3.3 vs. 0.8, P < 0.0001). Therefore, the average number of adolescents that respondents were willing to invite was significantly higher for adolescents than adults (1.9 vs. 0.7; P < 0.0001).

We found statistically significant positive correlations between the number of named family members (r = 0.29, P = 0.0016), friends (r = 0.22, P = 0.02), and sex- and drug-risk alters (r = 0.43, P = 0.0001) whom respondents were willing to engage in vaccine preparedness and their level of willingness to invite each group to participate in a future HIV vaccine study.

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DISCUSSION

To determine whether a social network approach might identify a high-risk cohort of adolescents for vaccine preparedness studies and future vaccine trials, we asked HIV-infected patients of a family-based HIV clinic to identify and recruit family members, friends, and sexual- and drug-risk partners to participate in an HIV vaccine preparedness study. Adolescents and adults were generally willing to name network members and provide information about them. Although participants were most likely to name family and friends, they also named sexual- and drug-risk partners and were willing to invite at least some in each group to participate in this study.

Adult participants were more willing than adolescents to invite network members. No differences were found by sex, risk behavior, or education. We also found that adults were more willing than adolescents to invite youth. However, adolescents named a greater number of adolescents and therefore the potential yield of youth for future studies is greater among adolescents than adults. This advantage might be mitigated by the greater difficulty of obtaining parental consent when adolescents identify other adolescents and the parent is not already participating in the study.

One concern about recruiting minors from adolescent referral is the risk of social harm resulting from network members' negative reactions to youth participation. This is a particular issue in the context of study procedures that actively encourage disclosure of study participation (ie, for the purpose of inviting network members to participate). Yet, by identifying important others for study participation, social network methodology can also facilitate educational efforts that address the public's limited knowledge of HIV vaccines. This in turn may mitigate negative attitudes toward trial participation.

Indexes were significantly more willing to invite network members who knew that the index was HIV infected. This suggests that concerns about confidentiality and inadvertent disclosure affected patients' willingness to engage associates. Similarly, willingness to engage associates could be affected by the requirement for HIV testing of alters. If testing would take place in the clinic where the index is receiving care, inadvertent disclosure of the index's HIV-positive status is a concern. As second- and third-degree alters are recruited in future studies using this methodology and the HIV-infected index becomes further removed from the recruitment process, disclosure concerns will become less relevant. However, the fact that HIV-infected indexes were more willing to recruit alters to whom they had disclosed than were first-degree alters to recruit second-degree alters indicates greater motivation due to their status. This emphasizes the importance of understanding the factors that influence willingness in a clinic-based setting. Future HIV vaccine trials will likely be conducted in this setting because medical providers and nursing staff will need to administer the vaccine and monitor vaccine side effects. Furthermore, youth-friendly clinic-based health care can enable the identification and recruitment of youth and facilitate their participation in clinical trials.34

Participants’ understanding of HIV infection is essential for understanding how a vaccine might work and is critical for informed consent. It is also an ethical necessity, given the possibility that risk behaviors might increase if youth mistakenly believe that they are protected from HIV acquisition by the candidate vaccine.10 Our results, although not statistically significant, suggest that HIV knowledge might also increase willingness to invite network members to participate in preparedness activities.

That we found no association between vaccine knowledge and willingness is consistent with some previous research on willingness to participate in vaccine trials.35,36 In contrast, in an earlier study, high-risk adults reported that receiving education about HIV vaccines and trial participation would be critical to their willingness.37 Possibly, vaccine preparedness activities are removed enough from actual trial participation to render concerns about the vaccine less salient. Alternatively, this outcome may reflect a lack of statistical power in our analysis and the fact that our questions were asked immediately after participants read the HIV vaccine fact sheet. We felt that the fact sheet was important because we expected that participants would know virtually nothing about HIV vaccines or vaccine trials at baseline.1,38 However, we may have measured short-term retention rather than actual vaccine knowledge in this baseline analysis. Our prospective design in the larger study will enable evaluation of long-term retention of this information.

Of interest in this research was whether willingness to invite alters to vaccine preparedness activities reflected willingness to engage them in hypothetical future HIV vaccine trials. The positive correlations we found suggest that because respondents overall were willing to engage most of the alters they named, social network methodology may lead to a high degree of engagement of alters into future HIV vaccine trials.

Given our interest in enrolling high-risk youth, of concern was the fact that participants were willing to invite the few named alters with whom they had had sex and used drugs but not necessarily those with whom they had had either sex or drug relationships. This is consistent with research on the role of multiplex vs. uniplex relations in social networks. Multiplex relations, in which individuals are linked on more than 1 relation39 (such as coworkers who are also friends), may have more interpersonal influence.40,41 The multiple links provide more opportunities for information exchange that can lead to a greater willingness to invite.

One limitation of this study was the lack of sufficient resources to investigate nonenrollment of alters whom indexes reported willingness to recruit (ie, whether the indexes or alters were actually not willing and the reasons for nonparticipation, including logistical issues, concerns about an HIV study, and fluctuating social networks). This information would have informed future efforts to develop such cohorts.

We have emphasized that network methods of referral may provide access to high-risk youth who may be critical recipients of a future vaccine and that an expected advantage of social network methodology is access to a cohort of youth well beyond that available by traditional approaches. To the extent that social network members share beliefs, values, and socioeconomic circumstances with HIV-infected important others, they are likely to be at increased risk themselves. The alters recruited here, however, reported fewer sexual and drug-using risk behaviors than expected. It is possible that our study design did not allow for the adequate identification of risk because we relied on self-reported measures and alters may have underreported their risk. Yet, this is more likely for clinic patients (indexes) who had established relationships with clinic providers than for alters, who did not have such relationships. In addition, we did not exclusively enroll high-risk indexes that would have increased the likelihood of a high-risk sample of alters. Future studies using social network methods should obtain biological measures, such as HIV and other STI tests, in addition to self-reported measures of risk, and enroll only those at high risk. Materials and procedures should encourage the recruitment of risk partners through interview scripts that reinforce commitment to confidentiality and the importance of involving risky others.

A related issue is generalizability-the extent to which our findings can inform the development of an adolescent cohort of social network members that originates from a clinic not similar to ours, for example, one that is not family-based or does not target HIV-infected youth. Whether our findings can be replicated in other clinics, both similar and different from ours, is a question for future research.

Results from this study have important implications for recruitment of adolescents into clinical trials testing HIV-preventive biological agents. The social networks of HIV-infected patients receiving care can be used to effectively recruit adolescent populations for trials and interventions. Even if effective preventive HIV vaccine trials do not include adolescents in the near future, it is essential to study techniques and develop procedures that will selectively identify and retain “hard to reach” at-risk youth for clinical trials and protect their rights as research subjects.

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ACKNOWLEDGMENTS

The authors acknowledge the invaluable contributions of Ernest Filart, Etopi Fanta, and Samali Lubega who helped develop materials, enroll participants, and collect data. We also thank Claire Schuster for editorial assistance and insights throughout the duration of the study and for facilitating input from the IMPAACT Community Advisory Board. We are also indebted to the IMPAACT Community Advisory Board, the MCA Community Advisory Board, and the Youth Advisory Board for their advice and to study participants for their involvement.

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REFERENCES

1. Coletti AS, Heagerty P, Sheon AR, et al. Randomized, controlled evaluation of a prototype informed consent process for HIV vaccine efficacy trials. J Acquir Immune Defic Syndr. 2003;32:161-169.

2. Brown-Peterside P, Chiasson MA, Ren L, et al. Involving women in HIV vaccine efficacy trials: lessons learned from a vaccine preparedness study in New York City. J Urban Health. 2000;77:425-437.

3. Buchbinder SP, Metch B, Holte SE, et al. Determinants of enrollment in a preventive HIV vaccine trial: hypothetical versus actual willingness and barriers to participation. J Acquir Immune Defic Syndr. 2004;36:604-612.

4. Bekker LG, Jaspan H, McIntyre J, et al. Adolescents and HIV vaccine trials: what are the clinical trial site issues? J Int Assoc Physicians AIDS Care. 2005;4:93-97.

5. Stanford PD, Monte DA, Briggs FM, et al. Recruitment and retention of adolescent participants in HIV research: findings from the REACH (reaching for excellence in adolescent care and health) project. J Adolesc Health. 2003;32:192-203.

6. Centers for Disease Control and Prevention (CDC). Fact sheet: young people at risk-epidemic shifts further toward young women and minorities. Atlanta, GA: The Centers; 1998.

7. Office of National AIDS Policy. Youth and HIV/AIDS 2000: A New American Agenda. Washington, DC: White House; 2000.

8. Mills E, Cooper C, Guyatt G, et al. Barriers to participating in an HIV vaccine trial: a systematic review. AIDS. 2004;18:2235-2242.

9. Fuchs J, Durham M, McLellan-Lemal E, et al. Negative social impacts among volunteers in an HIV vaccine efficacy trial. J Acquir Immune Defic Syndr. 2007;46:362-368.

10. Chesney MA, Chambers DB, Kahn JO. Risk behavior for HIV infection in participants in preventive HIV vaccine trials: a cautionary note. J Acquir Immune Defic Syndr. 1997;16:266-271.

11. Swartz L, Kagee A, Kafaar Z, et al. Social and behavioral aspects of child and adolescent participation in HIV vaccine trials. J Int Assoc Physicians AIDS Care. 2005;4:89-92.

12. Newman PA, Duan N, Lee S, et al. Willingness to participate in HIV vaccine trials: the impact of trial attributes. Prev Med. 2007;44:554-557.

13. Rogers AS. HIV prevention vaccine research in teens: what it will take. Presented at: Adolescent Trials Network/Title IV Youth Services Grantees Joint Meeting; April 14, 2004; Washington, D.C.

14. AIDS Vaccine Advocacy Coalition. AIDS Vaccine Trials-Getting the Global House in Order. New York: AIDS Vaccine Advocacy Coalition; 2004.

15. Valente TW, Vlahov D. Selective risk taking among needle exchange participants: implications for supplemental interventions. Am J Public Health. 2001;91:406-411.

16. Wasserman S, Faust K. Social Networks Analysis: Methods and Applications. Cambridge, United Kingdom: Cambridge University Press; 1994.

17. Morris M, ed. Network Epidemiology: A Handbook for Survey Design and Data Collection. New York: Oxford University Press; 2004.

18. Scott J. Network Analysis: A Handbook. 2nd ed. Newbury Park, CA: Sage; 2000.

19. Ellen J, Dolcini M, Bir ND, et al. Social network centrality and sexual experience among a household sample of urban African American adolescents. Connect. 2001;24:76-81.

20. Valente TW. Network Models of the Diffusion of Innovations. Cresskill, NJ: Hampton Press; 1995.

21. Seage GR III, Holte SE, Metzger D, et al. Are US populations appropriate for trials of human immunodeficiency virus vaccine? The HIVNET Vaccine Preparedness Study. Am J Epidemiol. 2001;153:619-627.

22. Choi K-H, McFarland W, Neilands TB, et al. An opportunity for prevention: prevalence, incidence, and sexual risk for HIV among young Asian and Pacific Islander men who have sex with men, San Francisco. Sex Transm Dis. 2004;31:475-480.

23. MacKellar D, Valleroy L, Karon J, et al. The Young Men's Survey: methods for estimating HIV seroprevalence and risk factors among young men who have sex with men. Public Health Rep. 1996;111:138-144.

24. Bartholow BN, MacQueen KM, Douglas JM Jr, et al. Assessment of the changing willingness to participate in phase III HIV vaccine trials among men who have sex with men. J Acquir Immune Defic Syndr. 1997;16:108-115.

25. CDC. Update: Syringe Exchange Programs-United States, 2002. Morb Mortal Wkly Rep (MMWR). 2005;54:673-676.

26. Abdul-Quader AS, Heckathorn DD, Sabin K, et al. Implementation and analysis of respondent driven sampling: lessons learned from the field. J Urban Health. 2006;83:i1-i5.

27. Broadhead RS, Heckathorn DD, Weakliem DL, et al. Harnessing peer networks as an instrument for AIDS prevention: results from a peer-driven intervention. Public Health Rep. 1998;113:42-57.

28. Heckathorn DD. Respondent-driven sampling: a new approach to the study of hidden populations. Soc Prob. 1997;44:174-199.

29. Heckathorn DD. Respondent-driven sampling II: deriving valid population estimates from chain-referral samples of hidden populations. Soc Prob. 2002;49:11-34.

30. Centers for Disease Control and Prevention (CDC). The Handbook for Evaluating HIV Education. Available at: http://www.cdc.gov/HealthyYouth/publications/hiv_handbook/hiv_booklet6/index.htm. Accessed January 22, 2004.

31. Murphy DA, Hoffman D, Seage GR III, et al. Improving comprehension for HIV vaccine trial information among adolescents at risk of HIV. AIDS Care. 2007;19:42-51.

32. Neaigus A, Friedman SR, Curtis R, et al. The relevance of drug injectors' social and risk networks for understanding and preventing HIV infection. Soc Sci Med. 1994;38:67-78.

33. Murray DM, Varnell SP, Blitstein JL. Design and analysis of group-randomized trials: a review of recent methodological developments. Am J Public Health. 2004;94:423-432.

34. Jaspan HB, Cunningham CK, Tucker TJ, et al. Inclusion of adolescents in preventive HIV vaccine trials: public health policy and research design at a crossroads. J Acquir Immune Defic Syndr. 2008;47:86-92.

35. Halpern SD, Metzger DS, Berlin JA, et al. Who will enroll? Predicting participation in a Phase II AIDS vaccine trial. J Acquir Immune Defic Syndr. 2001;27:281-288.

36. Priddy FH, Cheng AC, Salazar LF, et al. Racial and ethnic differences in knowledge and willingness to participate in HIV vaccine trials in an urban population in the Southeastern US. Int J STD AIDS. 2006;17:99-102.

37. Kegeles SM, Johnson MO, Strauss RP, et al. How should HIV vaccine efficacy trials be conducted? Diverse U.S. communities speak out. AIDS Educ Prev. 2006;18:560-572.

38. Koblin BA, Heagerty P, Sheon A, et al. Readiness of high-risk populations in the HIV Network for Prevention Trials to participate in HIV vaccine efficacy trials in the United States. AIDS. 1998;12:785-793.

39. Marsden PV. Core discussion networks of Americans. Am Sociol Rev. 1987;52:122-131.

40. Hartman RL, Johnson D. Social contagion and multiplexity communication networks as predictors of commitment and role ambiguity. Hum Commun Res. 1989;15:523-548.

41. Haythornthwaite C. Exploring multiplexity: social network structures in a computer-supported distance learning class. Inf Soc. 2001;17:211-226.

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Keywords:

HIV vaccine preparedness; HIV vaccines; social networks

© 2009 Lippincott Williams & Wilkins, Inc.

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