JAIDS Journal of Acquired Immune Deficiency Syndromes:
Epidemiology and Social Science
HIV-Infected Adults With a CD4 Cell Count Greater Than 500 Cells/mm3 on Long-Term Combination Antiretroviral Therapy Reach Same Mortality Rates as the General Population
Lewden, Charlotte MD, PhD*; Chêne, Geneviève MD, PhD*†; Morlat, Philippe MD, PhD*†; Raffi, François MD, PhD‡; Dupon, Michel MD, PhD†; Dellamonica, Pierre MD, PhD§; Pellegrin, Jean-Luc MD, PhD†; Katlama, Christine MD, PhD∥; Dabis, François MD, PhD*†; Leport, Catherine MD, PhD¶; and the Agence Nationale de Recherches sur le Sida et les Hépatites Virales (ANRS) CO8 APROCO-COPILOTE and CO3 AQUITAINE Study Groups
From *INSERM, U593, Bordeaux, France, and Institut de Santé Publique, d'Epidémiologie et de Developpement (ISPED), Université Victor Segalen Bordeaux 2, Bordeaux, France; †Centre Hospitalier Universitaire, Bordeaux, France; ‡Université de Nantes, Nantes, France; §Hôpital l'Archet, Nice, France; ∥Groupe Hospitalier Pitié-Salpêtrière, Paris, France; and ¶Université Paris 7 Denis Diderot, Paris, France.
Received for publication December 22, 2006; accepted June 5, 2007.
Financial support to the Agence Nationale de Recherches sur le Sida et les hépatites virales (ANRS) CO8 APROCO-COPILOTE Study Group provided by ANRS Action Coordonnée no. 7 (AC7), Sidaction Ensemble contre le Sida, and the following laboratories: Abbott, Boehringer-Ingelheim, Bristol-Myers Squibb, Glaxo-SmithKline, and Roche. Support to the ANRS CO8 APROCO-COPILOTE Study Group also provided by the Collège des Universitaires de Maladies Infectieuses et Tropicales (formerly Association des Professeurs de Pathologie Infectieuse et Tropicale). Financial support to the ANRS CO3 AQUITAINE Cohort provided by the ANRS AC7, Centre Hospitalier Universitaire de Bordeaux.
Data presented in part at the 10th European AIDS Conference/EACS, Dublin, Ireland, November 17-20, 2005.
Reprints: Charlotte Lewden, MD, PhD, INSERM U593, ISPED, 146 rue Léo-Saignat 33076 Bordeaux cedex, France (e-mail: firstname.lastname@example.org).
Objective: To compare mortality rates in combination antiretroviral therapy (cART)-treated HIV-infected adults with mortality in the general population according to the level of CD4 cell count reached and the duration of exposure to cART.
Methods: HIV-infected adults initiating a protease inhibitor-containing treatment between 1997 and 1999 were selected in the Agence Nationale de Recherches sur le Sida et les hépatites virales (ANRS) APROCO and AQUITAINE cohorts. CD4 cell counts were estimated during follow-up using a 2-phase mixed linear model. Standardized mortality ratios (SMRs) were computed in reference to the 2002 French population rates, overall and for the time period spent with a CD4 count ≥500 cells/mm3. To identify if and when mortality rates reached values of the general population, SMRs were computed successively with truncation at each year of follow-up.
Results: The 2435 adults (77% men, baseline median age = 36 years, and baseline median CD4 count = 270 cells/mm3) had a median follow-up of 6.8 years. The SMR was 7.0 (95% confidence interval [CI]: 6.2 to 7.8). During the 5402 person-years spent with a CD4 count ≥500 cells/mm3, the mortality reached the level of the general population after the sixth year after cART initiation (SMR = 0.5, 95% CI: 0.1 to 1.6).
Conclusion: Although overall mortality was higher in cART-treated HIV-infected adults, a subgroup with especially good prognosis can be identified, and these characteristics should be targeted for long-term treatment.
The availability of combination antiretroviral therapy (cART) has resulted in immune restoration in most treated HIV-infected patients and in a dramatic decrease in AIDS-related mortality.1-3 Provided that treatment is taken daily and there is regular follow-up, most cART-treated individuals have a social life that may include working, having children, or buying a house, because life expectancy has dramatically improved. Studies considering short-term or midterm follow-up after cART initiation have shown that mortality remained higher in HIV-infected individuals in the cART period than in the general population in France,4 Switzerland,5,6 and Denmark.7 Early favorable viroimmunologic response to treatment has proven to be associated with a longer survival, however, regardless of the initial CD4 cell count and plasma HIV RNA levels.8 We hypothesized that high values of CD4 cell counts attained might allow these patients to reach the same mortality rates as those of the general population in the long term. We thus compared mortality rates in HIV-infected adults after the first cART prescription with the mortality of the general population of the same age and gender according to the level of CD4 cell count reached and according to the duration of exposure to cART.
HIV-infected adults who started cART containing a protease inhibitor (PI) for the first time in 1997 to 1999 were identified from 2 well-established cohorts. Indeed, PI-containing regimens were the first available cART, and exposure to this category of cART is therefore the longest that can be observed among treated patients. Patients selected for this study may have been previously exposed to mono- or dual therapy with nucleoside reverse transcriptase inhibitors. The Agence Nationale de Recherches sur le Sida et les hépatites virales (ANRS) CO8 APROCO-COPILOTE cohort is a prospective observational study that consecutively enrolled 1281 HIV-1-infected adults in 47 hospital departments in France who were starting a PI-containing treatment for the first time in 1997 to 1999.9 Standardized clinical and biologic data were collected at baseline, after 1 and 4 months of cART, and every 4 months thereafter. Investigators were requested to notify the data management center of patient deaths as soon as they were known, and regular monitoring rounds were organized to monitor consistency between hospital files and case report forms. The ANRS CO3 AQUITAINE Cohort was implemented in 1987 by the Groupe d'Epidemiologie Clinique du Sida en Aquitaine (GECSA) based on a public hospital surveillance system of HIV-infected adults in the Aquitaine region of southwest France.10 Standardized clinical and biologic data are collected at each hospital contact and at least every 6 months. An active search of patients lost to follow-up is performed yearly. In both cohorts, patients signed informed consent forms.
Duplicate patient records between the 2 databases were excluded. We considered data on patients who remained alive up to December 31, 2005, or until loss to follow-up or death. Death rates were calculated per 100 person-years (PYs). Standardized mortality ratios (SMRs) were estimated with reference to the 2002 French general population death rates stratified for gender and for every 10 years of age,11 and the 95% confidence intervals (CIs) of the SMRs were estimated by the Byar approximation of the Poisson method.12
CD4 cell counts during follow-up were estimated using a mixed linear model to take into account unbalanced data attributable to missing at-random measurements13 and measurement error.14 Square root of CD4-positive values were fitted using a piecewise linear model allowing for a change of slope at 4 months15 and adjusted for baseline covariates: age, clinical AIDS stage, plasma HIV RNA level, history of antiretroviral treatment, and HIV transmission (injecting drug use vs. others). For each year of age during follow-up, 3 values of CD4 cell count were estimated (every 4 months), and the lowest value of the year was classified in the following categories: ≥500 cells/mm3, 350 to 499 cells/mm3, 200 to 349 cells/mm3, or <200 cells/mm3. Death rates and SMRs were estimated for the cumulated time period spent within each category of CD4 cell count.
To identify if and when during follow-up mortality rates reached values of the general population, we performed successive selections of patients with long-term follow-up. SMRs were computed successively with truncation at each year of follow-up for the 2 highest categories of CD4 cell count (≥500 cells/mm3 and 350 to 499 cells/mm3). For instance, for the analysis of time spent with a CD4 count ≥500 cells/mm3 and truncation at 6 years, a patient still followed 8 years after cART initiation may contribute to the analysis for the time spent with CD4 a cell count ≥500 cells/mm3 only after the sixth year of follow-up.
SMRs were also estimated according to HIV transmission group (injecting drug use vs. others) and hepatitis C virus (HCV) coinfection as defined by the presence of HCV antibody or plasma HCV RNA at baseline, because similar types of analyses reported higher mortality ratios in these groups.5,6
The underlying cause of death was ascertained with data available in the hospital file according to the International Classification of Diseases 10th revision (ICD-10) rules16 and adapted to the specificities in HIV infection.17
Statistical analyses were performed using Statistical Analysis System software (SAS, version 9.1; SAS Corporation, Cary, NC).
A total of 2435 patients (1281 from the APROCO-COPILOTE cohort and 1154 from the AQUITAINE cohort) were included in the analysis. The median patient age was 36 years; 77% were men; and HIV transmission categories were homosexual or bisexual in 38%, heterosexual in 35%, and injecting drug use in 21% of cases. Overall, 29% of patients were HCV infected (88% among patients infected through injecting drug use). The median CD4 count was 270 cells/mm3 at the time of cART initiation, 16% of patients had a CD4 cell count ≥500 cells/mm3, and 19% of patients had a CD4 cell count between 350 and 499 cells/mm3. At baseline, 22% had a previous AIDS-defining clinical event; 39% had previously received antiretroviral treatment with 1 or 2 drugs; and the first PI prescribed was indinavir in 43%, nelfinavir in 31%, saquinavir in 16%, and ritonavir in 15%.
Estimated CD4 counts were ≥500 cells/mm3 in 39% of the 1949 patients still followed 3 years after cART initiation and in 49% of the 1430 patients still followed at 6 years (Fig. 1). During a median follow-up of 6.8 years (interquartile range [IQR]: 4.1 to 7.9, 13,970 PYs), 288 individuals died, 2.1 deaths per 100 PYs (95% CI: 1.8 to 2.3). Overall mortality was 7.0 times higher than in the general population, 4.8 in men and 13.0 in women, 16.3 in injecting drug users, and 13.9 in HCV-coinfected patients (Table 1). Considering the total time spent within each category of CD4 cell count, mortality remained higher than in the general population in all categories and SMRs were gradually higher when CD4 cell counts were lower (Table 2). In patients with a CD4 count ≥500 cells/mm3, however, mortality reached the level of the general population after the sixth year after initiation of cART (SMR = 0.5, 95% CI: 0.1 to 1.6; Table 3; Fig. 2). Considering the time spent in the category of a CD4 count from 350 to 499 cells/mm3, the SMR was lower after 6 years but remained around twice the mortality of the general population (Table 4, Fig. 2). Overall, the underlying cause of death was AIDS related in 35% of cases, and in 52%, 21%, 15%, and 8% when the CD4 count at the age of death was <200 cells/mm3, 200 to 349 cells/mm3, 350 to 499 cells/mm3, and ≥500 cells/mm3, respectively.
In this study with a median follow-up of 7 years after cART initiation, age- and gender-adjusted overall mortality remained 7-fold higher in HIV-infected adults than in the general population. The mortality rate became similar to that of the general population after the sixth year of follow-up among patients whose CD4 counts had reached 500 cells/mm3, however.
Because we aimed at identifying if and when during follow-up mortality rates reached values of the general population, we selected patients who had the highest CD4 cell counts and were followed long term. Therefore, we cannot exclude a survivor bias, and we acknowledge that these results only apply to a specific subgroup. Nevertheless, identifying patients with the best prognosis, regardless of their history, may help to identify therapeutic objectives and formulate guidelines. That is the reason why we did not adjust for potential confounding factors such as previous antiretroviral exposure, baseline CD4 cell count and HIV RNA level, and type of treatment received, as we would have done in a classic prognosis study.
We acknowledge that our analysis may have some limitations. For this analysis, we considered that the 2 cohorts studied were similar enough to be pooled because they were located in the same country, where guidelines for the case management of HIV-infected patients are generally well known and followed by physicians.18 Moreover, epidemiologic and biostatistical support and data management are coordinated by the same epidemiology unit.
The level of CD4 cell count is known as a strong prognostic factor for the occurrence of AIDS-defining events and death. In our study, the proportion of non-AIDS-related causes of death increased with higher CD4 cell counts. Achieving the level of 500 cells/mm3 seemed to be associated with the same rates of mortality as among the general population after 6 years after cART, whereas it was still higher during a shorter time of follow-up. Among patients who spent time with a CD4 count between 350 and 499 cells/mm3, mortality remained higher than in the general population. Several interpretations of these observations are possible. First, the level of CD4 cell count is associated with mortality, even when the CD4 count is greater than 200 cells/mm3, because of the persistence of AIDS-defining or HIV-associated morbidities. For instance non-Hodgkin lymphoma remains a frequent cause of death among treated HIV-infected patients.17 Second, non-AIDS-defining morbidities such as bacterial infections or cancers may occur more frequently at an intermediate level of CD4 cell count.19 Nevertheless, even among patients with the highest category of CD4 cell count, the reason for the long period needed to reach the same mortality rates as in the general population remains to be clarified. We hypothesize that immune restoration after HIV infection may be a long-lasting process and that time is necessary to recover immune functions able to reduce mortality to the same level as in the general population. Another hypothesis may be that patients without severe comorbidities succeed more frequently in reaching a high CD4 cell count, and perhaps a longer time of follow-up.
Published studies have reported higher mortality in HIV-infected persons compared with the general population.4,6,7 Van Sighem et al20 found higher mortality in HIV-infected patients in The Netherlands even after having selected patients followed for at least 6 months and taking into account the CD4 cell count 6 months after cART initiation. In the Swiss cohort, Jaggy et al5 reported a moderate excess of death rates, compared with the general population, when the CD4 count reached 250 cells/mm3 at least once after cART.
Our analysis does not take into account some confounding factors that might at least partly explain differences in mortality rates. First, the risk of death from cardiovascular diseases or cancer might be related to the high proportion of smokers among HIV-infected individuals.21,22 Second, injecting drug users have a higher risk of death from overdose and violence.23 They are frequently coinfected with HCV, which exposes them to cirrhosis and hepatocarcinoma. In fact, mortality was higher among injecting drug users and HCV-infected patients in our analysis, in agreement with other studies.5,6,24 None of these characteristics was available in databases of the general population, nor were socioeconomic conditions or levels of education, which are associated with higher mortality in the general population25 as well as in treated HIV-infected patients.26 Confounding factors may thus explain the higher overall mortality compared with the general population and the higher SMR in women than in men, agreeing with a previous analysis in the APROCO-COPILOTE cohort4 and with other reports.6 The less favorable prognosis observed in HIV-infected women as compared with women in the general population could reflect a less favorable sociodemographic status of HIV-infected women and a higher frequency of comorbidities (29% of women were infected through injecting drug use and 30% were HCV infected). Other time-dependent markers of HIV progression (eg, HIV RNA level) are associated with mortality in the long term. Nevertheless, to our knowledge, the additional effect of HIV RNA level on mortality in patients with a high CD4 cell count has not been reported so far and would probably be weak.
Although patients who started PI-containing cART may not be representative of patients having started cART with more recent combinations, they can be considered as representative of the large number of patients, approximately 35,000 in France, who started cART in the years 1997 to 1999, who currently have the longest follow-up under cART. We excluded the year 1996 because it was the first year of cART being available in France and an intermediate period of implementation with heterogeneous practices. We can hypothesize that patients who started cART later than 1999 may have a better prognosis, because therapeutic strategies have improved,2 and that they may reach the same mortality rate more rapidly than the general population.
These results remain to be confirmed in other populations, and cohort collaborations may address this question with a larger sample size and a longer follow-up. Nevertheless, we believe that communicating these results to patients and physicians is already crucial to assist them in maintaining their efforts to achieve and sustain high CD4 cell counts through sustained adherence to cART. We acknowledge that our results are derived from a method using a selection of subgroups of patients, and thus may only be generalized to this specific population.
In countries in which a certificate of health status is required to obtain insurance contracts and loans, HIV infection with a favorable response to treatment in the long term might no longer be considered an obstacle, based on our observations. To improve prognosis in most HIV-infected patients, medical teams should evaluate all known factors associated with suboptimal response to treatment (ie, tolerance, adherence, social support, care of depression) to achieve the goal of sustained immune reconstitution. In addition to identifying factors that may hinder this objective,27 operational tools to improve complete therapeutic success should be developed and evaluated.
The authors thank the ANRS CO8 APROCO-COPILOTE Study Group (see Appendix). The authors also thank the ANRS CO3 AQUITAINE Cohort (see Appendix).
1. Mocroft A, Ledergerber B, Katlama C, et al. Decline in the AIDS and death rates in the EuroSIDA study: an observational study. Lancet
2. Collaboration CASCADE. Determinants of survival following HIV-1 seroconversion after the introduction of HAART. Lancet
3. Palella FJ Jr, Baker RK, Moorman AC, et al. Mortality in the highly active antiretroviral therapy era: changing causes of death and disease in the HIV Outpatient Study. J Acquir Immune Defic Syndr
4. Lewden C, Raffi F, Chêne G, et al. Mortality in a cohort of HIV-infected adults started on a protease inhibitor-containing therapy-standardization to the general population. J Acquir Immune Defic Syndr
5. Jaggy C, von Overbeck J, Ledergerber B, et al. Mortality in the Swiss HIV Cohort Study (SHCS) and the Swiss general population. Lancet
6. Keiser O, Taffe P, Zwahlen M, et al. All cause mortality in the Swiss HIV Cohort Study from 1990 to 2001 in comparison with the Swiss population. AIDS
7. Jensen-Fangel S, Pedersen L, Pedersen C, et al. Low mortality in HIV-infected patients starting highly active antiretroviral therapy: a comparison with the general population. AIDS
8. Chêne G, Sterne JA, May M, et al. Prognostic importance of initial response in HIV-1 infected patients starting potent antiretroviral therapy: analysis of prospective studies. Lancet
9. Le Moing V, Thiébaut R, Chêne G, et al. Predictors of long-term increase in CD4(+) cell counts in human immunodeficiency virus-infected patients receiving a protease inhibitor-containing antiretroviral regimen. J Infect Dis
10. Chêne G, Binquet C, Moreau JF, et al. Changes in CD4+ cell count and the risk of opportunistic infection or death after highly active antiretroviral treatment. Groupe d'Epidemiologie Clinique du SIDA en Aquitaine. AIDS
12. Breslow N, Day N. Statistical Methods in Cancer Research II. The Design and Analysis of Cohort Studies
. Lyon, France: World Health Organization-International Agency for Research on Cancer; 1987.
13. Laird N, Ware J. Random-effects models for longitudinal data. Biometrics
14. Dafni U, Tsiatis A. Evaluating surrogate markers of clinical outcome when measured with error. Biometrics
15. Thiébaut R, Chêne G, Jacqmin-Gadda H, et al. Time-updated CD4+
T-lymphocyte count and HIV RNA as major markers of disease progression in naive HIV-1-infected patients treated with a highly active antiretroviral therapy: the Aquitaine Cohort, 1996-2001. J Acquir Immune Defic Syndr
16. World Health Organization. International Classification of Diseases
, 10th revision. Geneva, Switzerland: World Health Organization; 1993.
17. Lewden C, Salmon D, Morlat P, et al. Causes of death among HIV-infected adults in the era of potent antiretroviral therapy: emerging role of hepatitis and cancers, persistent role of AIDS. Int J Epidemiol
18. Dormont J. Stratégies d'utilisation des antirétroviraux dans l'infection par le VIH. Rapport 1998
. Médecine sciences ed. Paris, France: Flammarion; 1998.
19. Clifford GM, Polesel J, Rickenbach M, et al. Cancer risk in the Swiss HIV Cohort Study: associations with immunodeficiency, smoking, and highly active antiretroviral therapy. J Natl Cancer Inst
20. van Sighem A, Danner S, Ghani AC, et al. Mortality in patients with successful initial response to highly active antiretroviral therapy is still higher than in non-HIV-infected individuals. J Acquir Immune Defic Syndr
21. Bénard A, Tessier J-F, Rambeloarisoa J, et al. HIV infection and tobacco smoking behaviour: prospects for prevention? ANRS CO3 Aquitaine Cohort, 2002. Int J Tuberc Lung Dis
22. Friis-Møller N, Sabin CA, Weber R, et al. Combination antiretroviral therapy and the risk of myocardial infarction. N Engl J Med
23. Frischer M, Bloor M, Goldberg D, et al. Mortality among injecting drug users: a critical reappraisal. J Epidemiol Community Health
24. Wang C, Vlahov D, Galai N, et al. Mortality in HIV-seropositive versus - seronegative persons in the era of highly active antiretroviral therapy: implications for when to initiate therapy. J Infect Dis
25. Jougla E, Rican S, Péquignot F, et al. La mortalité. In: Leclerc A, Fassin D, Grandjean H, et al, eds. Les inégalités sociales de santé
. Paris, France: Editions La découverte et Syros; 2000:147-162.
26. Lewden C, Raffi F, Cuzin L, et al. Factors associated with mortality in human immunodeficiency virus type 1-infected adults initiating protease inhibitor-containing therapy: role of education level and of early transaminase level elevation (APROCO-ANRS EP11 study). J Infect Dis
27. Kaufmann GR, Furrer H, Ledergerber B, et al. Characteristics, determinants, and clinical relevance of CD4 T cell recovery to <500 cells/μL in HIV type 1-infected individuals receiving potent antiretroviral therapy. Clin Infect Dis
ANRS CO8 APROCO-COPILOTE Study Group
Principal Investigators: C. Leport, F. Raffi
Epidemiology: G. Chêne, R. Salamon
Social Sciences: J-P. Moatti, J. Pierret, B. Spire
Virology: F. Brun-Vézinet, H. Fleury, B. Masquelier
Pharmacology: G. Peytavin, R. Garraffo
Other members: D. Costagliola, P. Dellamonica, C. Katlama, L. Meyer, M. Morin, D. Salmon, A. Sobel
Events Validation Committee: L. Cuzin, M. Dupon, X. Duval, V. Le Moing, B. Marchou, T. May, P. Morlat, C. Rabaud, A. Waldner-Combernoux
Project coordination: F. Collin
Observers: P. Bursacchi, JF. Delfraissy, J. Dormont, M. Garré
Clinical Research Group: V. Le Moing, C. Lewden
Clinical centers (coordinators): Amiens (Pr. J. L. Schmit), Angers (Dr. J. M. Chennebault), Belfort (Dr. J. P. Faller), Besançon (Pr. J. L. Dupond, Dr. J. M. Estavoyer, Pr. P. Humbert), Bobigny (Pr. A. Krivitzky), Bordeaux (Pr. M. Dupon, Pr. Longy-Boursier, Pr. P. Morlat, Pr. J. M. Ragnaud), Bourg-en-Bresse (Dr. P. Granier), Brest (Pr. M. Garré), Caen (Pr. R. Verdon), Compiègne (Dr. Y. Domart), Corbeil Essonnes (Dr. A. Devidas), Créteil (Pr. A. Sobel), Dijon (Pr. H. Portier), Garches (Pr. C. Perronne), Lagny (Dr. P. Lagarde), Libourne (Dr. J. Ceccaldi), Lyon (Pr. D. Peyramond), Meaux (Dr. C. Allard), Montpellier (Pr. J. Reynes), Nancy (Pr. T. May), Nantes (Pr. F. Raffi), Nice (Pr. J.P. Cassuto, Pr. P. Dellamonica), Orléans (Dr. P. Arsac), Paris (Pr. E. Bouvet, Pr. F. Bricaire, Pr. P. Bergmann, Pr. J. Cabane, Dr. G. Cessot, Pr. P. M. Girard, Pr. L. Guillevin, Pr. S. Herson, Pr. C. Leport, Pr. M. C. Meyohas, Pr. J. M. Molina, Pr. G. Pialoux, Pr. D. Salmon), Poitiers (Pr. B. Becq-Giraudon), Reims (Pr. R. Jaussaud), Rennes (Pr. C. Michelet), Saint-Etienne (Pr. F. Lucht), Saint-Mandé (Pr. T. Debord), Strasbourg (Pr. J. M. Lang), Toulon (Dr. J. P. De Jaureguiberry), Toulouse (Pr. B. Marchou), Tours (Pr. J. M. Besnier)
Data monitoring and statistical analysis: C. Alfaro, F. Alkaied, S. Boucherit, A. D. Bouhnik, C. Brunet-François, M.P. Carrieri, M. Courcoul, F. Couturier, J. L. Ecobichon, M. François, L. Iordache, V. Journot, P. Kurkdji, J. P. Legrand, E. Lootvoet, E. Pereira, M. Préau, C. Protopopescu, J. Surzyn, A. Taieb, F. Tourteau, V. Villes, H. Zouari
ANRS CO3 AQUITAINE Cohort
Epidemiology: G. Chêne, F. Dabis, C. Lewden, S. Lawson-Ayayi, R. Thiébaut, M. Winnock
Infectious Diseases-Internal Medicine: M. Dupon, P. Mercié, J. F. Moreau, P. Morlat, J. L. Pellegrin, J. M. Ragnaud, D. Neau, N. Bernard, D. Lacoste, D. Malvy
Immunology: J.-F. Moreau, P. Blanco
Virology: H. Fleury, M. E. Lafon, B. Masquelier, I. Pellegrin
Pharmacovigilance: G. Miremont
Clinical Pharmacology: D. Breilh
Monitoring, data management, and statistical analysis: E. Balestre, M.J. Blaizeau, M. Decoin, S. Delveaux, L. Dequae-Merchadou, D. Dutoit, S. Geffard, C. Hannapier, L. Houinou, S. Labarrère, V. Lavignolle-Aurillac, G. Palmer, D. Touchard, B. Uwamaliya-Nziyumvira
Clinical centers (participating physicians)
Bordeaux University Hospital: P. Morlat (N. Bernard, M. Bonarek, F. Bonnet, K. Lacombe, P. Gellie, D. Lacoste, F. Paccalin, M. C. Pertusa), M. Dupon (H. Dutronc, F. Dauchy, S. Lafarie), M. Longy-Boursier (P. Mercié, A. Aslan, D. Malvy, T. Pistonne, M.-C. Receveur, P. Thibaut), J. M. Ragnaud (D. Neau, C. Cazanave, D. Chambon, C. De La Taille, A. Ochoa), J. L. Pellegrin (J.F. Viallard, O. Caubet, C. Nouts), P. Couzigou
Dax Hospital: P. Loste (L. Caunègre)
Bayonne Hospital: F. Bonnal (S. Farbos, M.C. Gemain).
Libourne Hospital: J. Ceccaldi (S. Tchamgoué).
Mont de Marsan Hospital: S. De Witte Cited Here...
This article has been cited 66 time(s).
Expert Review of Anti-Infective TherapyThe MOTIVATE trials: maraviroc therapy in antiretroviral treatment-experienced HIV-1-infected patientsExpert Review of Anti-Infective Therapy
Cold Spring Harbor Perspectives in MedicineNovel Cell and Gene Therapies for HIVCold Spring Harbor Perspectives in Medicine
Bmc Infectious DiseasesAll-cause mortality in the cohorts of the Spanish AIDS Research Network (RIS) compared with the general population: 1997-2010Bmc Infectious Diseases
AIDS Research and TherapyShould highly active antiretroviral therapy be prescribed in critically ill HIV-infected patients during the ICU stay? A retrospective cohort studyAIDS Research and Therapy
Quality of Life ResearchThe impact of denial on health-related quality of life in patients with HIVQuality of Life Research
Advances in Immunology, Vol 119Residual Immune Dysregulation Syndrome in Treated HIV infectionAdvances in Immunology, Vol 119
BloodThe immunologic effects of maraviroc intensification in treated HIV-infected individuals with incomplete CD4+ T-cell recovery: a randomized trialBlood
Journal of the American Pharmacists AssociationFederal Bureau of Prisons HIV consultant pharmacist monitoring and advisory programJournal of the American Pharmacists Association
Medicina ClinicaNeoplasms and HIV in the epidemic's third decadeMedicina Clinica
International Journal of EpidemiologyCauses of death in HIV-infected women: persistent role of AIDS. The 'Mortalite 2000 & 2005' Surveys (ANRS EN19)International Journal of Epidemiology
Journal of Antimicrobial ChemotherapyNovel strategies to treat antiretroviral-naive HIV-infected patientsJournal of Antimicrobial Chemotherapy
CirculationAssessing Risk for Cardiovascular Disease in Patients With Human Immunodeficiency Virus Why it MattersCirculation
Clinical Infectious DiseasesChanges in Cancer Mortality among HIV-Infected Patients: The Mortalite 2005 SurveyClinical Infectious Diseases
HIV MedicineAnkle-branch index and HIV: the role of antiretroviralsHIV Medicine
Clinical Infectious DiseasesCD4(+) T Cell Recovery with Antiretroviral Therapy: More Than the Sum of the PartsClinical Infectious Diseases
British Medical JournalHIV infection, antiretroviral treatment, ageing, and non-AIDS related morbidityBritish Medical Journal
Revue De Medecine InterneHuman immunodeficiency virus infection, 25 years laterRevue De Medecine Interne
Australian Family Physician
Long term management of people with HIV
Australian Family Physician, 38(8):
Clinical Infectious DiseasesRole of Uncontrolled HIV RNA Level and Immunodeficiency in the Occurrence of Malignancy in HIV-Infected Patients during the Combination Antiretroviral Therapy Era: Agence Nationale de Recherche sur le Sida (ANRS) CO3 Aquitaine CohortClinical Infectious Diseases
Clinical TrialsMethodological issues in the use of composite endpoints in clinical trials: examples from the HIV fieldClinical Trials
Journal of Antimicrobial ChemotherapyWhen and why to start antiretroviral therapy?Journal of Antimicrobial Chemotherapy
Journal of VirologyAntiretroviral Therapy in the ClinicJournal of Virology
Enfermedades Infecciosas Y Microbiologia ClinicaRecommendations from the GESIDA/Spanish AIDS Plan regarding antiretroviral treatment in adults with human immunodeficiency virus infection (update February 2009)Enfermedades Infecciosas Y Microbiologia Clinica
Antimicrobial Agents and ChemotherapyInhibition of Envelope-Mediated CD4(+)-T-Cell Depletion by Human Immunodeficiency Virus Attachment InhibitorsAntimicrobial Agents and Chemotherapy
Clinical Infectious DiseasesCellular CD4 T Cell Responses to the Diphtheria-Derived Carrier Protein of Conjugated Pneumococcal Vaccine and Antibody Response to Pneumococcal Vaccination in HIV-Infected AdultsClinical Infectious Diseases
Revue De Medecine InterneAntiretroviral therapy in human immunodeficiency virus infection: An updateRevue De Medecine Interne
Nature MedicineCCL3L1-CCR5 genotype influences durability of immune recovery during antiretroviral therapy of HIV-1-infected individualsNature Medicine
Revue De Medecine InterneChronicity of HIV infection in emerging diseases in seropositivesRevue De Medecine Interne
Archives of Internal Medicine
Triple-Class Virologic Failure in HIV-Infected Patients Undergoing Antiretroviral Therapy for Up to 10 Years
Archives of Internal Medicine, 170(5):
M S-Medecine Sciences
Clinic and transmission of HIV in women: literature review
M S-Medecine Sciences, 24():
M S-Medecine Sciences
Mortality rate of HIV-infected adults on long term combination antiretroviral therapy
M S-Medecine Sciences, 24():
American Journal of EpidemiologyThe Study to Understand the Natural History of HIV and AIDS in the Era of Effective Therapy (SUN Study)American Journal of Epidemiology
Epidemiology and InfectionMarkov modelling of HIV infection evolution in the HAART eraEpidemiology and Infection
Plos OneEarly Antiretroviral Therapy Reduces AIDS Progression/Death in Individuals with Acute Opportunistic Infections: A Multicenter Randomized Strategy TrialPlos One
Journal of Sexual MedicineSexually Transmitted Diseases and Sexual FunctionJournal of Sexual Medicine
Archives of Womens Mental HealthCorrelates of HIV stigma in HIV-positive womenArchives of Womens Mental Health
Medecine Et Maladies Infectieuses
Formalized consensus: HIV infection care in general and city medicine
Medecine Et Maladies Infectieuses, 39():
Jama-Journal of the American Medical Association
Antiretroviral treatment of adult HIV infection - 2008 recommendations of the International AIDS Society USA panel
Jama-Journal of the American Medical Association, 300(5):
Clinical Infectious DiseasesIncomplete Peripheral CD4(+) Cell Count Restoration in HIV-Infected Patients Receiving Long-Term Antiretroviral TreatmentClinical Infectious Diseases
International Journal of EpidemiologyMortality of HIV-infected patients starting potent antiretroviral therapy: comparison with the general population in nine industrialized countriesInternational Journal of Epidemiology
HIV MedicineIs long-term virological response related to CCR5 delta 32 deletion in HIV-1-infected patients started on highly active antiretroviral therapy?HIV Medicine
Human Gene Therapy MethodsCD25 Preselective Anti-HIV Vectors for Improved HIV Gene TherapyHuman Gene Therapy Methods
Journal of Korean Medical ScienceTrends of Mortality and Cause of Death among HIV-Infected Patients in Korea, 1990-2011Journal of Korean Medical Science
Journal of Health Care for the Poor and Underserved
HIV, Tobacco Use, and Poverty: A Potential Cause of Disparities in Health Status by Race and Socioeconomic Status
Journal of Health Care for the Poor and Underserved, 24(3):
Journal of Clinical HypertensionLow Nadir CD4 Cell Count Predicts Sustained Hypertension in HIV-Infected IndividualsJournal of Clinical Hypertension
Future VirologyImpact of age on markers of HIV-1 diseaseFuture Virology
Future MicrobiologyDoes the success of HIV treatment depend on gender?Future Microbiology
Expert Opinion on Biological TherapyUsing TRIM5 alpha as an HIV therapeutic: the alpha gene?Expert Opinion on Biological Therapy
Role of Interleukin-2 in Patients with HIV Infection
Antiretroviral therapy and management of HIV infection
Clinical Infectious DiseasesRate of CD4(+) Cell Count Increase over Periods of Viral Load Suppression: Relationship with the Number of Previous Virological FailuresClinical Infectious Diseases
Current Opinion in HIV and AIDSFifteen million people on antiretroviral treatment by 2015: treatment as preventionCurrent Opinion in HIV and AIDS
Journal of the American Dental Association
The role of the dental profession in addressing the human immunodeficiency virus epidemic
Journal of the American Dental Association, 144():
Plos OneLong-Term Survival in HIV Positive Patients with up to 15 Years of Antiretroviral TherapyPlos One
Current Opinion in Infectious DiseasesSexual risk behaviour of men who have sex with men: emerging patterns and new challengesCurrent Opinion in Infectious Diseases
Current Opinion in Infectious DiseasesShould HIV therapy be started at a CD4 cell count above 350 cells/μl in asymptomatic HIV-1-infected patients?Current Opinion in Infectious Diseases
Current Opinion in OncologyEvolving epidemiology of malignancies in HIVCurrent Opinion in Oncology
JAIDS Journal of Acquired Immune Deficiency SyndromesAssociation of HIV Infection, Demographic and Cardiovascular Risk Factors With All-Cause Mortality in the Recent HAART EraJAIDS Journal of Acquired Immune Deficiency Syndromes
JAIDS Journal of Acquired Immune Deficiency SyndromesCD4+ T-Cell Restoration After 48 Weeks in the Maraviroc Treatment-Experienced Trials MOTIVATE 1 and 2JAIDS Journal of Acquired Immune Deficiency Syndromes
JAIDS Journal of Acquired Immune Deficiency SyndromesNo Variability Across Centers in Adherence and Response to HAART in French Hospitals: Results From the ANRS-EN12-VESPA StudyJAIDS Journal of Acquired Immune Deficiency Syndromes
antiretroviral therapy; highly active; CD4 cell count; HIV infection; mortality; response to treatment; standardized mortality ratio
© 2007 Lippincott Williams & Wilkins, Inc.
What does "Remember me" mean?
By checking this box, you'll stay logged in until you logout. You'll get easier access to your articles, collections,
media, and all your other content, even if you close your browser or shut down your
To protect your most sensitive data and activities (like changing your password),
we'll ask you to re-enter your password when you access these services.
What if I'm on a computer that I share with others?
If you're using a public computer or you share this computer with others, we recommend
that you uncheck the "Remember me" box.
Highlight selected keywords in the article text.
Data is temporarily unavailable. Please try again soon.
Readers Of this Article Also Read