Enter your Email address:
Wolters Kluwer Health may email you for journal alerts and information, but is committed
to maintaining your privacy and will not share your personal information without
Tulpule, Anil; Espina, Byron M.; Palmer, Maria; Schiflett, Joanne; Harvey-Buchanan, Laura; Levine, Alexandra M.
USC/Norris Cancer Hospital, Los Angeles, CA 90033
BACKGROUND: AIDS-lymphoma is the second most common malignancy in patients with HIV infection. First line combination chemotherapy is associated with complete remission in approximately 50%. No standard second line therapy has been defined in relapsed or refractory patients. We wished to explore the efficacy of pegylated L-asparaginase (Oncaspar) in this patient population. Oncaspar has previously shown efficacy against high grade lymphoid malignancies.
METHODS: Four dose levels of Oncaspar are being studied in relapsed/refractory AIDS-NHL. The dose for cohort 1 is 1500 IU/m2 given IM every two weeks.
RESULTS: Thus far, two patients have been accrued. Their characteristics and study results are shown below: Table
Both patients have had biopsy-proven complete disease resolution. Adverse effects consisted of low fibrinogen, prolonged APTT, and moderate fatigue in both; mild nausea, anorexia, and elevated cholesterol in one patient.
CONCLUSION: We conclude that Oneaspar has good preliminary evidence of anti-tumor activity in patients with refractory AIDS-NHL within minimal side effects. Accrual is ongoing.
Bethesda, Maryland April 6-8, 1998
Sponsored by the National Cancer Institute
© Lippincott-Raven Publishers.
Colleague's E-mail is Invalid
Your Name: (optional)
Separate multiple e-mails with a (;).
Thought you might appreciate this item(s) I saw at JAIDS Journal of Acquired Immune Deficiency Syndromes.
Send a copy to your email
Your message has been successfully sent to your colleague.
Some error has occurred while processing your request. Please try after some time.
An Existing Folder
A New Folder
The item(s) has been successfully added to "".
Login with your LWW Journals username and password.
Username or Email:
Enter and submit the email address you registered with. An email with instructions to reset your password will be sent to that address.
Link to reset your password has been sent to specified email address.
What does "Remember me" mean?
By checking this box, you'll stay logged in until you logout. You'll get easier access to your articles, collections,
media, and all your other content, even if you close your browser or shut down your
To protect your most sensitive data and activities (like changing your password),
we'll ask you to re-enter your password when you access these services.
What if I'm on a computer that I share with others?
If you're using a public computer or you share this computer with others, we recommend
that you uncheck the "Remember me" box.
Save my selection
Article Level Metrics