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Chen, Iris BS*; Cummings, Vanessa BS, MT (ASCP)*; Fogel, Jessica M. PhD*; Marzinke, Mark A. PhD*; Clarke, William PhD*; Connor, Matthew B. MS†; Griffith, Sam MAT‡; Buchbinder, Susan MD§; Shoptaw, Steven PhD‖; del Rio, Carlos MD¶; Magnus, Manya PhD, MPH#; Mannheimer, Sharon MD**; Wheeler, Darrell P. PhD, MPH, ASCW††; Mayer, Kenneth H. MD‡‡; Koblin, Beryl A. PhD§§; Eshleman, Susan H. MD, PhD*
Abstract: HIV RNA levels are usually high early in HIV infection. In the HPTN 061 study, men were tested for HIV infection every 6 months; 6 (21.4%) of 28 men who acquired HIV infection during the study had low or undetectable HIV RNA at the time of HIV diagnosis. Antiretroviral drugs were not detected at the time of HIV diagnosis. False-negative HIV test results were obtained for 2 men using multiple assays. Antiretroviral drug resistance mutations were detected in HIV from 1 man. Additional studies are needed to identify factors associated with low HIV RNA levels during early HIV infection.
© 2014 by Lippincott Williams & Wilkins
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HIV, seroconversion, viral load, HIV controllers, diagnosis
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