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JAIDS Journal of Acquired Immune Deficiency Syndromes:
doi: 10.1097/QAI.0000000000000270
Brief Report: Epidemiology and Prevention

Clinical Performance of Digital Cervicography and Cytology for Cervical Cancer Screening in HIV-Infected Women in Lusaka, Zambia

Bateman, Allen C. PhD, MPH*,†; Parham, Groesbeck P. MD*,†,‡; Sahasrabuddhe, Vikrant V. MBBS, DrPH§; Mwanahamuntu, Mulindi H. MBBS, MMed*,‡; Kapambwe, Sharon MBChB, MPH*; Katundu, Katundu MSc*; Nkole, Theresa MD, MMed; Mulundika, Jacqueline MBChB, MMed, MPH; Pfaendler, Krista S. MD; Hicks, Michael L. MD; Shibemba, Aaron MD, MMed; Vermund, Sten H. MD, PhD§; Stringer, Jeffrey S.A. MD*,†; Chibwesha, Carla J. MD, MSc*,†

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Abstract: Although there is a growing literature on the clinical performance of visual inspection with acetic acid in HIV-infected women, to the best of our knowledge, none have studied visual inspection with acetic acid enhanced by digital cervicography. We estimated clinical performance of cervicography and cytology to detect cervical intraepithelial neoplasia grade 2 or worse. Sensitivity and specificity of cervicography were 84% [95% confidence interval (CI): 72 to 91) and 58% (95% CI: 52 to 64). At the high-grade squamous intraepithelial lesion or worse cutoff for cytology, sensitivity and specificity were 61% (95% CI: 48 to 72) and 58% (95% CI: 52 to 64). In our study, cervicography seems to be as good as cytology in HIV-infected women.

© 2014 by Lippincott Williams & Wilkins


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