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JAIDS Journal of Acquired Immune Deficiency Syndromes:
doi: 10.1097/QAI.0000000000000227
Brief Report: Clinical Science

Weight as Predictors of Clinical Progression and Treatment Failure: Results From the TREAT Asia Pediatric HIV Observational Database

Kariminia, Azar PhD*; Durier, Nicolas MD, MPH; Jourdain, Gonzague MD, PhD; Saghayam, Suneeta MSc, PhD§; Do, Chau V. MD; Nguyen, Lam Van MD; Hansudewechakul, Rawiwan MD#; Lumbiganon, Pagakrong MD**; Chokephaibulkit, Kulkanya MD††; Truong, Khanh Huu MD‡‡; Sirisanthana, Virat MD§§; Ung, Vibol MD‖‖; Vonthanak, Saphonn MD, PhD¶¶; Ananworanich, Jintanat MD, PhD##; Nik Yusoff, Nik Khairulddin MD***; Kurniati, Nia MD†††; Azahar Razali, Kamarul MD‡‡‡; Fong, Moy Siew MBBS§§§; Nallusamy, Revathy MBBS‖‖‖; Wati, Dewi Kumara MD¶¶¶

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Abstract

Objective: To evaluate the value of time-updated weight and height in predicting clinical progression, and immunological and virological failure in children receiving combination antiretroviral therapy (cART).

Methods: We used Cox regression to analyze data of a cohort of Asian children.

Results: A total of 2608 children were included; median age at cART was 5.7 years. Time-updated weight for age z score < −3 was associated with mortality (P < 0.001) independent of CD4% and < −2 was associated with immunological failure (P ≤ 0.03) independent of age at cART.

Conclusions: Weight monitoring provides useful data to inform clinical management of children on cART in resource-limited settings.

© 2014 by Lippincott Williams & Wilkins

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