Skip Navigation LinksHome > August 15, 2014 - Volume 66 - Issue 5 > Effects of Different Antigenic Stimuli on Thymic Function an...
JAIDS Journal of Acquired Immune Deficiency Syndromes:
doi: 10.1097/QAI.0000000000000207
Basic and Translational Science

Effects of Different Antigenic Stimuli on Thymic Function and Interleukin-7/CD127 System in Patients with Chronic HIV Infection

Castro, Pedro MD, PhD*; Torres, Berta MD; López, Anna MD, PhD; González, Raquel MD§,‖; Vilella, Anna MD, PhD§,‖; Nicolas, Jose M. MD, PhD*; Gallart, Teresa MD‡,¶; Pumarola, Tomàs MD, PhD#; Sánchez, Marcelo MD, PhD**; Leal, Manuel MD, PhD††; Vallejo, Alejandro MD, PhD††; Bayas, José M. MD, PhD§; Gatell, José M. MD, PhD; Plana, Montserrat MD, PhD; García, Felipe MD, PhD

Collapse Box


Background: We tested if an increase in immune activation and a decrease in CD4+ T cells induced by different antigenic stimuli could be associated with changes in the thymic function and the interleukin (IL)-7/CD127 system.

Methods: Twenty-six HIV-infected patients under combined antiretroviral therapy (cART) were randomized to receive, during 12 months, a complete immunization schedule (7 vaccines and 15 doses) or placebo. Thereafter, cART was interrupted during 6 months. Changes in the thymic function and the IL-7/CD127 system after 3 different antigenic stimuli (vaccines, episodes of low-level intermittent viremia before cART interruption, or viral load rebound after cART interruption) were assessed.

Results: During the period on cART, neither vaccines nor low-level viremia influenced thymic function or IL-7/CD127 system parameters. By analyzing the cohort as a whole while on cART, a significant improvement was observed in the thymic function as measured by an increase in the thymic volume (P = 0.024), T-cell receptor excision circle–bearing cells (P = 0.012), and naive CD4+ and CD8+ T cells (P = 0.069 both). No significant changes were observed in the IL-7/CD127 system. After cART interruption, a decrease in T-cell receptor excision circles (P < 0.001) and naive CD8+ T cells (P < 0.001), an increase in IL-7 and expression of CD127 on naive and memory CD4+ T cells (P = 0.028, P = 0.088, and P = 0.04, respectively), and a significant decrease in CD127 on naive and memory CD8+ T cells (P = 0.01, P = 0.006, respectively) were observed.

Conclusions: Low-level transient antigenic stimuli during cART were not associated with changes in the thymic function or the IL-7/CD127 system. Conversely, viral load rebound very early after cART interruption influenced the thymic function and the IL-7/CD127 system. Clinical number NCT00329251.

© 2014 by Lippincott Williams & Wilkins


Article Level Metrics

Search for Similar Articles
You may search for similar articles that contain these same keywords or you may modify the keyword list to augment your search.