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JAIDS Journal of Acquired Immune Deficiency Syndromes:
doi: 10.1097/QAI.0B013E31822D0433
Brief Report: Clinical Science

The Interrelated Transmission of HIV-1 and Cytomegalovirus During Gestation and Delivery in the Offspring of HIV-Infected Mothers

Khamduang, Woottichai MS*†; Jourdain, Gonzague MD, PhD*†‡; Sirirungsi, Wasna PhD*; Layangool, Prapaisri MD§; Kanjanavanit, Suparat MD‖; Krittigamas, Pornsuda MD‖; Pagdi, Karin MD¶; Somsamai, Rosalin MD¶; Sirinontakan, Surat MD#; Hinjiranandana, Temsiri MD**; Ardonk, Wanna MD††; Hongsiriwon, Suchat MD‡‡; Nanta, Sirisak MD§§; Borkird, Thitiporn MD‖‖; Lallemant, Marc MD*†‡; McIntosh, Kenneth MD‡¶; Ngo-Giang-Huong, Nicole PharmD, PhD*†‡; For the Program for HIV Prevention and Treatment (PHPT) Study Group

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Our objective was to analyze, in formula-fed infants, correlates of HIV mother-to-child transmission, including cytomegalovirus (CMV) infection. HIV-infected infants were matched with HIV uninfected by maternal HIV RNA in a case-control design. Infant CMV infection was determined by CMV IgG at 18 months and timed by earlier CMV IgM or CMV DNA. Correlations were assessed using logistic regression. In utero HIV infection was independently associated with congenital CMV infection (P = 0.01), intrapartum HIV infection with congenital-plus-intrapartum/neonatal CMV infection (P = 0.01), and overall HIV with overall CMV infection (P = 0.001), and prematurity (P = 0.004). Congenital and acquired CMV infections are strong independent correlates of mother-to-child HIV transmission.

© 2011 Lippincott Williams & Wilkins, Inc.


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