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JAIDS Journal of Acquired Immune Deficiency Syndromes:
doi: 10.1097/QAI.0000000000000227
Brief Report: PDF Only

Weight as predictors of clinical progression and treatment failure: Results from the TREAT Asia Pediatric HIV Observational Database (TApHOD).

Kariminia, Azar PhD; Durier, Nicolas MD, MPH; Jourdain, Gonzague MD, PhD; Saghayam, Suneeta MSc; Do, Chau V. MD; Nguyen, Van L. MD; Hansudewechakul, Rawiwan MD; Lumbiganon, Pagakrong MD; Chokephaibulkit, Kulkanya MD; Truong, Huu K. MD; Sirisanthana, Virat MD; Ung, Vibol MD; Vonthanak, Saphonn MD, PhD; Ananworanich, Jintanat MD, PhD; Yusoff, Nik Khairulddin N.; Kurniati, Nia MD; Razali, Kamarul MD; Fong, Siew M. MBBS; Nallusamy, Revathy MBBS; Wati, Dewi K. MD

Published Ahead-of-Print
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Abstract

Objective: To evaluate the value of time-updated weight and height in predicting clinical progression, immunological and virological failure in children receiving combination antiretroviral therapy (cART).

Methods: We used Cox regression to analyse data of a cohort of Asian children.

Results: 2608 children were included; median age at cART was 5.7 years. Time-updated weight for age Z score <-3 was associated with mortality (P < 0.001) independent of CD4%; and <-2 was associated with immunological failure (P <= 0.03) independent of age at cART.

Conclusion: Weight monitoring provides useful data to inform clinical management of children on cART in resource-limited settings.

(C) 2014 by Lippincott Williams & Wilkins

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