Objective: To evaluate the value of time-updated weight and height in predicting clinical progression, immunological and virological failure in children receiving combination antiretroviral therapy (cART).
Methods: We used Cox regression to analyse data of a cohort of Asian children.
Results: 2608 children were included; median age at cART was 5.7 years. Time-updated weight for age Z score <-3 was associated with mortality (P < 0.001) independent of CD4%; and <-2 was associated with immunological failure (P <= 0.03) independent of age at cART.
Conclusion: Weight monitoring provides useful data to inform clinical management of children on cART in resource-limited settings.
(C) 2014 by Lippincott Williams & Wilkins