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JAIDS Journal of Acquired Immune Deficiency Syndromes:
doi: 10.1097/QAI.0b013e31822d0433
Brief Report: PDF Only

The interrelated transmission of human immunodeficiency virus type 1 and cytomegalovirus during gestation and delivery in the offspring of HIV-infected mothers.

Khamduang, Woottichai M.S; Jourdain, Gonzague M.D., Ph.D.; Sirirungsi, Wasna Ph.D.; Layangool, Prapaisri M.D.; Kanjanavanit, Suparat M.D.; Krittigamas, Pornsuda M.D.; Pagdi, Karin M.D.; Somsamai, Rosalin M.D.; Sirinontakan, Surat M.D.; Hinjiranandana, Temsiri M.D.; Ardonk, Wanna M.D.; Hongsiriwon, Suchat M.D.; Nanta, Sirisak M.D.; Borkird, Thitiporn M.D.; Lallemant, Marc M.D.; McIntosh, Kenneth M.D.; Ngo-Giang-Huong, Nicole Pharm.D. Ph.D.; for the Program for HIV Prevention Treatment (PHPT) study group

Published Ahead-of-Print
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Our objective was to analyze, in formula-fed infants, correlates of HIV mother-to-child transmission, including cytomegalovirus (CMV) infection.

HIV-infected infants were matched with HIV-uninfected by maternal HIV RNA in a case-control design. Infant CMV infection was determined by CMV-IgG at 18 months and timed by earlier CMV-IgM or -DNA. Correlations were assessed using logistic regression.

In utero HIV infection was independently associated with congenital CMV infection (P=0.01), intrapartum HIV infection with congenital-plus-intrapartum/neonatal CMV infection (P=0.01), and overall HIV with overall CMV infection (P=0.001), as well as prematurity (P=0.004).

Congenital and acquired CMV infections are strong independent correlates of mother-to-child HIV transmission.

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