Progress in HIV treatments has led to HIV-infected patients living into their 60s and older. Since HIV-associated Neurocognitive Disorder (HAND) in older age is associated with more executive dysfunction, cognitive screening instruments tapping this domain may be optimal. We examined the Montreal Cognitive Assessment (MoCA) to identify HAND in 67 HIV-infected patients over age 60, of which 40% were diagnosed with HAND. Receiver operator characteristics (ROC) curve identified an optimized cut-off <=25/30 identified HAND with a sensitivity of 72% and specificity of 67%. We conclude that the MoCA has only moderate performance characteristics for cognitive screening of HIV-infected elders.
(C) 2014 by Lippincott Williams & Wilkins